D-erythro-Neopterin

Names

[ CAS No. ]:
2009-64-5

[ Name ]:
D-erythro-Neopterin

[Synonym ]:
2-Amino-6-[(1S,2R)-1,2,3-trihydroxypropyl]-4(1H)-pteridinone
Crithidia Factor
2-Amino-6-[(1S,2R)-1,2,3-trihydroxypropyl]pteridin-4(3H)-one
1-(2-amino-4-hydroxy-pteridin-6-yl)propane-1,2,3-triol
EINECS 217-924-7
2-Amino-6-[(1S,2R)-1,2,3-trihydroxypropyl]pteridin-4(8H)-one
D-Neopterin
2-Amino-6-[(1S,2R)-1,2,3-trihydroxypropyl]-4(1H)-ptéridinone
MFCD00042801
4(8H)-pteridinone, 2-amino-6-[(1S,2R)-1,2,3-trihydroxypropyl]-
6-(1',2',3'-Trihydroxy)pterin
D(+)-Neopterin 10MG
D(+)-6-(ERYTHRO-1,2,3-TRIHYDROXYPROPYL)PTERIN
D-neopterine
Gavestinel
D-(+)-Neopterin
D-(PLUS)-NEOPTERINE
2-amino-6-((1S,2R)-1,2,3-trihydroxy-propyl)-3H-pteridin-4-one
(+)-NEOPTERIN
D-erythro-neopterin
4(3H)-Pteridinone, 2-amino-6-[(1S,2R)-1,2,3-trihydroxypropyl]-
2-Amino-6-[(1S,2R)-1,2,3-trihydroxypropyl]-4(1H)-pteridinon
Neopterin
D(+)-Neopterin
2-amino-6-(1,2,3-trihydroxy-propyl)-3H-pteridin-4-one
2-AMino-6-[(1S,2R)-1,2,3-trihydroxypropyl]

Biological Activity

[Description]:

D-(+)-Neopterin, a catabolic product of guanosine triphosphate (GTM), serves as a marker of cellular immune system activation.

[Related Catalog]:

Research Areas >> Inflammation/Immunology

Natural Products >> Saccharides and Glycosides

[Target]

Human Endogenous Metabolite

[References]

[1]. Murr C, et al. Neopterin as a Marker for Immune System Activation. Current Drug Metabolism [01 Apr 2002, 3(2):175-187].

[Related Small Molecules]

Chemical & Physical Properties

[ Density]:
2.0±0.1 g/cm3

[ Boiling Point ]:
697.7ºC at 760mmHg

[ Melting Point ]:
>232ºC (dec.)

[ Molecular Formula ]:
C₉H₁₁N₅O₄

[ Molecular Weight ]:
253.215

[ Flash Point ]:
375.7ºC

[ Exact Mass ]:
253.081100

[ PSA ]:
158.50000

[ LogP ]:
-4.57

[ Index of Refraction ]:
1.860

MSDS

Click to get detail MSDS

Safety Information

[ Symbol ]:

GHS07

[ Signal Word ]:
Warning

[ Hazard Statements ]:
H315-H319-H335

[ Precautionary Statements ]:
P261-P305 + P351 + P338

[ Personal Protective Equipment ]:
dust mask type N95 (US);Eyeshields;Gloves

[ Hazard Codes ]:
Xi: Irritant;

[ Risk Phrases ]:
36/37/38

[ Safety Phrases ]:
26

[ RIDADR ]:
NONH for all modes of transport

[ HS Code ]:
2933990090

Synthetic Route

Click to get detail synthetic route

Precursor & DownStream

Precursor

DownStream

Customs

[ HS Code ]: 2933990090

[ Summary ]:
2933990090. heterocyclic compounds with nitrogen hetero-atom(s) only. VAT:17.0%. Tax rebate rate:13.0%. . MFN tariff:6.5%. General tariff:20.0%

Articles

Increased serum levels of quinolinic acid indicate enhanced severity of hepatic dysfunction in patients with liver cirrhosis.

Hum. Immunol. 74(1) , 60-6, (2013)

The Model for End-Stage Liver Disease (MELD) score is a tool for assessment of the degree of hepatic insufficiency/failure. Quinolinic acid (QuinA) is a tryptophan metabolite produced by activated mac...

A community-based study on determinants of circulating markers of cellular immune activation and kynurenines: the Hordaland Health Study.

Clin. Exp. Immunol. 173(1) , 121-30, (2013)

Circulating neopterin and kynurenine/tryptophan ratio (KTR) increase during inflammation and serve as markers of cellular immune activation, but data are sparse on other determinants of these markers ...

Interferon (IFN)-γ-mediated inflammation and the kynurenine pathway in relation to bone mineral density: the Hordaland Health Study.

Clin. Exp. Immunol. 176(3) , 452-60, (2014)

The risk of osteoporosis increases in inflammatory disorders. In cell-mediated immune activation, interferon (IFN)-γ stimulates macrophage release of neopterin and increases the activity of indoleamin...

Related Compounds

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