RORγ-IN-1

Names

[ Name ]:
RORγ-IN-1

[Synonym ]:
5H-Pyrrolo[3,4-b]pyridine-3-carboxamide, N-[[5-(ethylsulfonyl)-2-pyridinyl]methyl]-6,7-dihydro-7-(1-methylethyl)-6-[[trans-4-(trifluoromethyl)cyclohexyl]methyl]-, (7S)-
(7S)-N-{[5-(Ethylsulfonyl)-2-pyridinyl]methyl}-7-isopropyl-6-{[trans-4-(trifluoromethyl)cyclohexyl]methyl}-6,7-dihydro-5H-pyrrolo[3,4-b]pyridine-3-carboxamide

Biological Activity

[Description]:

RORγ-IN-1 is a RORγ inhibitor extracted from patent US 9481674 B1, has a Ki of <100 nM.

[Related Catalog]:

Signaling Pathways >> Metabolic Enzyme/Protease >> ROR

Research Areas >> Inflammation/Immunology

Research Areas >> Metabolic Disease

[Target]

Ki: <100 nM (RORγ)[1]

[References]

[1]. David A. Claremon, et al. Dihydropyrrolopyridine inhibitors of ROR-gamma . US 9481674 B1.

[Related Small Molecules]

SR1078 | LYC-55716 | SR3335 | ROR gamma-t-IN-1 | SR1001 | GSK2981278 | SR2211 | Gne-0946 | GNE-6468 | L 601920-0 | SR 0987 | TMP778

Chemical & Physical Properties

[ Density]:
1.3±0.1 g/cm3

[ Boiling Point ]:
659.4±55.0 °C at 760 mmHg

[ Molecular Formula ]:
C₂₇H₃₅F₃N₄O₃S

[ Molecular Weight ]:
552.652

[ Flash Point ]:
352.6±31.5 °C

[ Exact Mass ]:
552.238220

[ LogP ]:
2.54

[ Vapour Pressure ]:
0.0±2.0 mmHg at 25°C

[ Index of Refraction ]:
1.541

Related Compounds

The content on this webpage is sourced from various professional data sources. If you have any questions or concerns regarding the content, please feel free to contact service1@chemsrc.com.