GSK2981278

Names

[ Name ]:
GSK2981278

[Synonym ]:
N-(4-Ethyl-phenyl)-3-hydroxymethyl-N-isobutyl-4-(tetrahydro-pyran-4-ylmethoxy)-benzenesulfonamide
Benzenesulfonamide, N-(4-ethylphenyl)-3-(hydroxymethyl)-N-(2-methylpropyl)-4-[(tetrahydro-2H-pyran-4-yl)methoxy]-
N-(4-Ethylphenyl)-3-(hydroxymethyl)-N-isobutyl-4-(tetrahydro-2H-pyran-4-ylmethoxy)benzenesulfonamide
GSK2981278

Biological Activity

[Description]:

GSK2981278 is a retinoid-related orphan receptor gamma (RORy) modulator, extracted from patent WO/2015061515 A1, example 124.

[Related Catalog]:

Signaling Pathways >> Metabolic Enzyme/Protease >> ROR

Research Areas >> Inflammation/Immunology

[References]

[1]. Birault Veronique, et al. Preparation of tetrahydropyranylmethoxy benzenesulfonamide compounds as RORγ modulators useful in therapy of various diseases. From PCT Int. Appl. (2015), WO 2015061515 A1 20150430.

[2]. Birault Veronique, et al. Preparation of tertiary N-arylbenzenesulfonamides as RORγ modulators useful in treatment of inflammatory, metabolic, and autoimmune diseases. From PCT Int. Appl. (2013), WO 2013160418 A1 20131031.

[Related Small Molecules]

SR1078 | LYC-55716 | SR3335 | ROR gamma-t-IN-1 | SR1001 | SR2211 | GNE-0946 | GNE-6468 | L 601920-0 | RORγ-IN-1 | SR 0987 | TMP778

Chemical & Physical Properties

[ Density]:
1.2±0.1 g/cm3

[ Boiling Point ]:
622.6±65.0 °C at 760 mmHg

[ Molecular Formula ]:
C₂₅H₃₅NO₅S

[ Molecular Weight ]:
461.614

[ Flash Point ]:
330.3±34.3 °C

[ Exact Mass ]:
461.223602

[ LogP ]:
4.00

[ Vapour Pressure ]:
0.0±1.9 mmHg at 25°C

[ Index of Refraction ]:
1.564