GNE-0946

Names

[ CAS No. ]:
1677667-24-1

[ Name ]:
GNE-0946

Biological Activity

[Description]:

GNE-0946 is a potent and selective RORγ( RORc) agonist with an EC50 value of 4 nM for HEK-293 cell.

[Related Catalog]:

Signaling Pathways >> Metabolic Enzyme/Protease >> ROR
Research Areas >> Inflammation/Immunology

[References]

[1]. Fauber BP, et al. Discovery of imidazo[1,5-a]pyridines and -pyrimidines as potent and selective RORc inverse agonists. Bioorg Med Chem Lett. 2015 Aug 1;25(15):2907-12.


[Related Small Molecules]

SR1078 | LYC-55716 | SR3335 | ROR gamma-t-IN-1 | SR1001 | GSK2981278 | SR2211 | GNE-6468 | L 601920-0 | RORγ-IN-1 | SR 0987 | TMP778

Chemical & Physical Properties

[ Molecular Formula ]:
C22H12ClF3N2O4

[ Molecular Weight ]:
460.79

Related Compounds