BACE2-IN-1

Names

[ CAS No. ]:
1676107-08-6

[ Name ]:
BACE2-IN-1

Biological Activity

[Description]:

BACE2-IN-1 (compound 3l) is a highly selective BACE2 inhibitor with a Ki value of 1.6 nM. BACE2 inhibitors can be used to research of Type 2 Diabetes[1].

[Related Catalog]:

Signaling Pathways >> Neuronal Signaling >> Beta-secretase
Research Areas >> Metabolic Disease

[Target]

BACE2:1.6 nM (Ki)

BACE1:815.1 nM (Ki)


[In Vitro]

BACE2-IN-1 (compound 3l) inhibits BACE2 with an Ki value of 1.6 nM, 500 fold over BACE1 (Ki = 815.1 nM)[1].

[References]

[1]. Ghosh AK, et al. Highly Selective and Potent Human β-Secretase 2 (BACE2) Inhibitors against Type 2 Diabetes: Design, Synthesis, X-ray Structure and Structure-Activity Relationship Studies. ChemMedChem. 2019 Mar 5. 14(5):545-560.

Chemical & Physical Properties

[ Molecular Formula ]:
C36H38F3N3O3

[ Molecular Weight ]:
617.70

Related Compounds