Sumanirole Maleate

Names

[ Name ]:
Sumanirole Maleate

[Synonym ]:
cc-479
(5R)-5-(Methylamino)-5,6-dihydro-4H-imidazo[4,5,1-ij]quinolin-2(1H)-one (2Z)-2-butenedioate (1:1)
4H-Imidazo[4,5,1-ij]quinolin-2(1H)-one, 5,6-dihydro-5-(methylamino)-, (5R)-, (2Z)-2-butenedioate (1:1)
UNII-2OI87T3R1B
S2191_Selleck
Sumanirole (maleate)

Biological Activity

[Description]:

Sumanirole maleate(PNU 95666E; U95666E) is a highly selective D2 receptor full agonist with an ED50 of about 46 nM.IC50 value: 46 nM (EC50)Target: D2 receptorSumanirole was developed for the treatment of Parkinson's disease and restless leg syndrome. While it has never been approved for medical use. Sumanirole is a highly valuable tool compound for basic research to identify neurobiological mechanisms that are based on a dopamine D2-linked (vs. D1, D3, D4, and D5-linked) mechanism of action.

[Related Catalog]:

Signaling Pathways >> GPCR/G Protein >> Dopamine Receptor

Signaling Pathways >> Neuronal Signaling >> Dopamine Receptor

Research Areas >> Neurological Disease

[References]

[1]. Arthur G. Romero, et al. Synthesis of the Selective D2 Receptor Agonist PNU-95666E fromD-Phenylalanine Using a Sequential Oxidative CyclizationStrategy. J. Org. Chem. 1997, 62, 6582-6587

[Related Small Molecules]

Chemical & Physical Properties

[ Molecular Formula ]:
C₁₅H₁₇N₃O₅

[ Molecular Weight ]:
319.313

[ Exact Mass ]:
319.116821

[ PSA ]:
124.42000

[ LogP ]:
0.57640

[ Storage condition ]:
-20℃

MSDS

Click to get detail MSDS

Safety Information

[ RIDADR ]:
NONH for all modes of transport

Articles

Effect of GDNF on depressive-like behavior, spatial learning and key genes of the brain dopamine system in genetically predisposed to behavioral disorders mouse strains.

Behav. Brain Res. 274 , 1-9, (2014)

The effect of glial cell line-derived neurotrophic factor (GDNF) on behavior and brain dopamine system in predisposed to depressive-like behavior ASC (Antidepressant Sensitive Cataleptics) mice in com...

Related Compounds

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