Emamectin Benzoate

Names

[ Name ]:
Emamectin Benzoate

[Synonym ]:
(2aE,4E,5'S,6S,6'R,7S,8E,11R,13S,15S,17aR,20R,20aR,20bS)-20,20b-dihydroxy-5',6,8,19-tetramethyl-6'-[(1S)-1-methylpropyl]-17-oxo-5',6,6',10,11,14,15,17,17a,20,20a,20b-dodecahydro-2H,7H-spiro[11,15-methanofuro[4,3,2-pq][2,6]benzodioxacyclooctadecine-13,2'-pyran]-7-yl 2,6-dideoxy-3-O-methyl-4-O-[2,4,6-trideoxy-3-O-methyl-4-(methylammonio)-a-L-arabino-hexopyranosyl]-a-L-arabino-hexopyranoside benzoate
Emamectin Benzoate
(1'R,2S,4'S,5S,6R,8'R,10'E,12'S,13'S,14'E,16'E,20'R,21'R,24'S)-6-[(2S)-2-Butanyl]-21',24'-dihydroxy-5,11',13',22'-tetramethyl-2'-oxo-5,6-dihydrospiro[pyran-2,6'-[3,7,19]trioxatetracyclo[15.6.1.1. 0]pentacosa[10,14,16,22]tetraen]-12'-yl 2,6-dideoxy-3-O-methyl-4-O-[2,4,6-trideoxy-3-O-methyl-4-(methylammonio)-α-L-arabino-hexopyranosyl]-α-L-arabino-hexopyranoside benzoate
(2aE,4E,5'S,6S,6'R,7S,8E,11R,13S,15S,17aR,20R,20aR,20bS)-20,20b-dihydroxy-5',6,8,19-tetramethyl-6'-[(1S)-1-methylpropyl]-17-oxo-5',6,6',10,11,14,15,17,17a,20,20a,20b-dodecahydro-2H,7H-spiro[11,15-meth
Emamectin (Benzoate)
(4''R)-4''-Deoxy-4''-(methylamino)-avermectin B1 benzoate

Biological Activity

[Description]:

Emamectin Benzoate (MK-244) works as a chloride channel activator by binding gamma aminobutyric acid (GABA) receptor and glutamate-gated chloride channels disrupting nerve signals within arthropods.

[Related Catalog]:

Signaling Pathways >> Membrane Transporter/Ion Channel >> GABA Receptor

Signaling Pathways >> Neuronal Signaling >> GABA Receptor

Research Areas >> Infection

[Target]

GABA Receptor

[In Vitro]

Emamectin Benzoate stimulates the release of GABA from the synapses between nerve cells and while additionally increasing GABA's affinity for its receptor on the post-junction membrane of muscle cells in insects and arthropods.

[References]

[1]. Cheng X, et al. Effect of Emamectin Benzoate on Root-Knot Nematodes and Tomato Yield. PLoS One. 2015 Oct 28;10(10):e0141235.

[Related Small Molecules]

Chemical & Physical Properties

[ Melting Point ]:
141-146ºC

[ Molecular Formula ]:
C₁₀₄H₁₅₄N₂O₂₈

[ Molecular Weight ]:
1880.33

[ PSA ]:
206.57000

[ LogP ]:
4.62840

MSDS

Click to get detail MSDS

Toxicological Information

CHEMICAL IDENTIFICATION

RTECS NUMBER :: CL1203005

CHEMICAL NAME :: Avermectin b', 4''-deoxy-4''-(methylamino)-, (4''R)-, benzoate (salt)

CAS REGISTRY NUMBER :: 155569-91-8

LAST UPDATED :: 199712

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

TYPE OF TEST :: TDLo - Lowest published toxic dose

ROUTE OF EXPOSURE :: Oral

DOSE :: 105 mg/kg

SEX/DURATION :: female 6-21 day(s) after conception lactating female 21 day(s) post-birth

TOXIC EFFECTS :: Reproductive - Maternal Effects - other effects Reproductive - Effects on Newborn - growth statistics (e.g.%, reduced weight gain) Reproductive - Effects on Newborn - behavioral

REFERENCE :: NETEEC Neurotoxicology and Teratology. (Pergamon Press Inc., Maxwell House, Fairview Park, Elmsford, NY 10523) V.9- 1987- Volume(issue)/page/year: 19,315,1997

Safety Information

[ Hazard Codes ]:
T,N,Xi

[ Risk Phrases ]:
25-36-50-57-58-36/37/38-50/53-23-21

[ Safety Phrases ]:
26-36-45-60-61-36/37

[ RIDADR ]:
UN 2811 6.1/PG 3

[ RTECS ]:
CL1203005

Related Compounds

The content on this webpage is sourced from various professional data sources. If you have any questions or concerns regarding the content, please feel free to contact service1@chemsrc.com.