Iminodiacetic acid

Names

[ CAS No. ]:
142-73-4

[ Name ]:
Iminodiacetic acid

[Synonym ]:
2-(carboxymethylamino)acetic acid
Iminodiacetic acid
N-(carboxymethyl)- glycine
MFCD00004280
diglycine
IDA
EINECS 205-555-4
Glycine, N-(carboxymethyl)-
2,2'-Azanediyldiacetic acid
2,2'-Iminodiacetic acid

Biological Activity

[Description]:

Iminodiacetic acid (IDA) is a chelating agent that strongly binds transition metals[1]. Iminodiacetic acid can be used for removal of toxic metal ions from water[2]. Iminodiacetic acid can serve as a biomarker to potentially predict the severity of ARDS (acute respiratory distress syndrome)[3].

[Related Catalog]:

Research Areas >> Others

Signaling Pathways >> Others >> Others

[References]

[1]. M D Loberg, et al. Development of new radiopharmaceuticals based on N-substitution of iminodiacetic acid. J Nucl Med. 1976 Jul;17(7):633-8.

[2]. Misra RK, et al. Iminodiacetic acid functionalized cation exchange resin for adsorptive removal of Cr(VI), Cd(II), Ni(II) and Pb(II) from their aqueous solutions. J Hazard Mater. 2011 Jan 30;185(2-3):1508-12.

[3]. Shihui Lin, et al. Explore potential plasma biomarkers of acute respiratory distress syndrome (ARDS) using GC-MS metabolomics analysis. Clin Biochem. 2019 Apr;66:49-56.

Chemical & Physical Properties

[ Density]:
1.4±0.1 g/cm3

[ Boiling Point ]:
370.6±27.0 °C at 760 mmHg

[ Melting Point ]:
243 °C (dec.)(lit.)

[ Molecular Formula ]:
C₄H₇NO₄

[ Molecular Weight ]:
133.10

[ Flash Point ]:
177.9±23.7 °C

[ Exact Mass ]:
133.037506

[ PSA ]:
86.63000

[ LogP ]:
-1.40

[ Vapour Pressure ]:
0.0±1.8 mmHg at 25°C

[ Index of Refraction ]:
1.501

[ Water Solubility ]:
2.43 g/100 mL (5 ºC)

MSDS

Click to get detail MSDS

Toxicological Information

CHEMICAL IDENTIFICATION

RTECS NUMBER :: AI2975000

CHEMICAL NAME :: Acetic acid, iminodi-

CAS REGISTRY NUMBER :: 142-73-4

BEILSTEIN REFERENCE NO. :: 0878499

LAST UPDATED :: 199710

DATA ITEMS CITED :: 4

MOLECULAR FORMULA :: C4-H7-N-O4

MOLECULAR WEIGHT :: 133.12

WISWESSER LINE NOTATION :: QV1M1VQ

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Intraperitoneal

SPECIES OBSERVED :: Rodent - mouse

DOSE/DURATION :: 250 mg/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

REFERENCE :: NTIS** National Technical Information Service. (Springfield, VA 22161) Formerly U.S. Clearinghouse for Scientific & Technical Information. Volume(issue)/page/year: AD277-689 *** NIOSH STANDARDS DEVELOPMENT AND SURVEILLANCE DATA *** NIOSH OCCUPATIONAL EXPOSURE SURVEY DATA : NOES - National Occupational Exposure Survey (1983) NOES Hazard Code - X4728 No. of Facilities: 25 (estimated) No. of Industries: 4 No. of Occupations: 5 No. of Employees: 293 (estimated) No. of Female Employees: 43 (estimated)

Safety Information

[ Symbol ]:

GHS07

[ Signal Word ]:
Warning

[ Hazard Statements ]:
H315-H319-H335

[ Precautionary Statements ]:
P261-P305 + P351 + P338

[ Personal Protective Equipment ]:
dust mask type N95 (US);Eyeshields;Gloves

[ Hazard Codes ]:
Xi:Irritant;

[ Risk Phrases ]:
R36/37/38

[ Safety Phrases ]:
S26-S36-S37/39

[ RIDADR ]:
NONH for all modes of transport

[ WGK Germany ]:
1

[ RTECS ]:
AI2975000

[ HS Code ]:
29224995

Synthetic Route

Click to get detail synthetic route

Precursor & DownStream

Precursor

DownStream

Customs

[ HS Code ]: 2922499990

[ Summary ]:
HS:2922499990 other amino-acids, other than those containing more than one kind of oxygen function, and their esters; salts thereof VAT:17.0% Tax rebate rate:9.0% Supervision conditions:AB(certificate of inspection for goods inward,certificate of inspection for goods outward) MFN tariff:6.5% General tariff:30.0%

Articles

Selective Solid-Phase Extraction of Zinc(II) from Environmental Water Samples Using Ion Imprinted Activated Carbon.

J. AOAC Int. 98(1) , 206-12, (2015)

A simple ion imprinted amino-functionalized sorbent was synthesized by coupling activated carbon with iminodiacetic acid, a functional compound for metal chelating, through cyanoric chloride spacer. T...

Quantitative structure-activity relationship and complex network approach to monoamine oxidase A and B inhibitors.

J. Med. Chem. 51 , 6740-51, (2008)

The work provides a new model for the prediction of the MAO-A and -B inhibitor activity by the use of combined complex networks and QSAR methodologies. On the basis of the obtained model, we prepared ...

Immobilized metal affinity chromatography using open tubular capillary for phosphoprotein analysis: comparison between polymer brush coating and surface functionalization.

J. Chromatogr. B. Analyt. Technol. Biomed. Life Sci. 879(27) , 2852-9, (2011)

In the present article, open tubular-IMAC columns, functionalized by iminodiacetic acid (IDA) for the immobilization of Fe(3+), were prepared by in situ chemical modification of fused silica capillary...