nitrilotriacetic acid
Names
[ CAS No. ]:
139-13-9
[ Name ]:
nitrilotriacetic acid
[Synonym ]:
nitrilotriacetate
combretastatin A2
aminotriacetic acid
Prochlorperazin
MFCD00004287
N,N-Bis(carboxymethyl)glycine,NTA,Tris(carboxymethyl)amine
2,2',2''-Nitrilotriacetic acid
tri(carboxymethyl)amine
Triglycine
Nitrilotriessigsaeure
EINECS 205-355-7
Glycine, N,N-bis(carboxymethyl)-
nitriloacetate
N,N-bis(carboxymethoxy)glycine
nitrilotriacetic acid
Triglycollamic acid
prochlorperazine Maleate
Tris(carboxymethyl)amine
α,α',α''-Trimethylaminetricarboxylic acid
Ntana3
Prochlorperazinemaleat
UNII-KA90006V9D
N,N-Bis(carb
a,a',a''-Trimethylaminetricarboxylic Acid
NTA
Complexon I
Biological Activity
[Description]:
[Related Catalog]:
Chemical & Physical Properties
[ Density]:
1.6±0.1 g/cm3
[ Boiling Point ]:
498.2±40.0 °C at 760 mmHg
[ Melting Point ]:
245 °C (dec.)(lit.)
[ Molecular Formula ]:
C6H9NO6
[ Molecular Weight ]:
191.139
[ Flash Point ]:
255.1±27.3 °C
[ Exact Mass ]:
191.042984
[ PSA ]:
115.14000
[ LogP ]:
-1.76
[ Vapour Pressure ]:
0.0±2.7 mmHg at 25°C
[ Index of Refraction ]:
1.558
[ Water Solubility ]:
Insoluble.
MSDS
Toxicological Information
CHEMICAL IDENTIFICATION
- RTECS NUMBER :
- AJ0175000
- CHEMICAL NAME :
- Acetic acid, nitrilotri-
- CAS REGISTRY NUMBER :
- 139-13-9
- BEILSTEIN REFERENCE NO. :
- 1710776
- LAST UPDATED :
- 199710
- DATA ITEMS CITED :
- 19
- MOLECULAR FORMULA :
- C6-H9-N-O6
- MOLECULAR WEIGHT :
- 191.16
- WISWESSER LINE NOTATION :
- QV1N1VQ1VQ
HEALTH HAZARD DATA
ACUTE TOXICITY DATA
- TYPE OF TEST :
- LD50 - Lethal dose, 50 percent kill
- ROUTE OF EXPOSURE :
- Oral
- SPECIES OBSERVED :
- Rodent - rat
- DOSE/DURATION :
- 1100 mg/kg
- TOXIC EFFECTS :
- Details of toxic effects not reported other than lethal dose value
- TYPE OF TEST :
- LD50 - Lethal dose, 50 percent kill
- ROUTE OF EXPOSURE :
- Oral
- SPECIES OBSERVED :
- Rodent - mouse
- DOSE/DURATION :
- 3160 mg/kg
- TOXIC EFFECTS :
- Details of toxic effects not reported other than lethal dose value
- TYPE OF TEST :
- LD50 - Lethal dose, 50 percent kill
- ROUTE OF EXPOSURE :
- Intraperitoneal
- SPECIES OBSERVED :
- Rodent - mouse
- DOSE/DURATION :
- 325 mg/kg
- TOXIC EFFECTS :
- Details of toxic effects not reported other than lethal dose value
- TYPE OF TEST :
- TDLo - Lowest published toxic dose
- ROUTE OF EXPOSURE :
- Oral
- SPECIES OBSERVED :
- Rodent - rat
- DOSE/DURATION :
- 41292 mg/kg/7W-C
- TOXIC EFFECTS :
- Kidney, Ureter, Bladder - changes in tubules (including acute renal failure, acute tubular necrosis)
- TYPE OF TEST :
- TDLo - Lowest published toxic dose
- ROUTE OF EXPOSURE :
- Oral
- SPECIES OBSERVED :
- Rodent - rat
- DOSE/DURATION :
- 29439 ug/kg/4W-C
- TOXIC EFFECTS :
- Kidney, Ureter, Bladder - other changes in urine composition Kidney, Ureter, Bladder - changes in bladder weight Nutritional and Gross Metabolic - changes in calcium
- TYPE OF TEST :
- TDLo - Lowest published toxic dose
- ROUTE OF EXPOSURE :
- Oral
- SPECIES OBSERVED :
- Rodent - rat
- DOSE/DURATION :
- 430 gm/kg/75W-C
- TOXIC EFFECTS :
- Tumorigenic - Carcinogenic by RTECS criteria Kidney, Ureter, Bladder - tumors
- TYPE OF TEST :
- TDLo - Lowest published toxic dose
- ROUTE OF EXPOSURE :
- Oral
- SPECIES OBSERVED :
- Rodent - mouse
- DOSE/DURATION :
- 832 gm/kg/66W-C
- TOXIC EFFECTS :
- Tumorigenic - neoplastic by RTECS criteria Kidney, Ureter, Bladder - tumors
MUTATION DATA
- TYPE OF TEST :
- Morphological transformation
- TEST SYSTEM :
- Rodent - hamster Embryo
- DOSE/DURATION :
- 2 gm/L
- REFERENCE :
- MUREAV Mutation Research. (Elsevier Science Pub. B.V., POB 211, 1000 AE Amsterdam, Netherlands) V.1- 1964- Volume(issue)/page/year: 356,85,1996 *** REVIEWS *** IARC Cancer Review:Animal Sufficient Evidence IMEMDT IARC Monographs on the Evaluation of Carcinogenic Risk of Chemicals to Man. (WHO Publications Centre USA, 49 Sheridan Ave., Albany, NY 12210) V.1- 1972- Volume(issue)/page/year: 48,181,1990 IARC Cancer Review:Human No Adequate Data IMEMDT IARC Monographs on the Evaluation of Carcinogenic Risk of Chemicals to Man. (WHO Publications Centre USA, 49 Sheridan Ave., Albany, NY 12210) V.1- 1972- Volume(issue)/page/year: 48,181,1990 IARC Cancer Review:Group 2B IMEMDT IARC Monographs on the Evaluation of Carcinogenic Risk of Chemicals to Man. (WHO Publications Centre USA, 49 Sheridan Ave., Albany, NY 12210) V.1- 1972- Volume(issue)/page/year: 48,181,1990 *** NIOSH STANDARDS DEVELOPMENT AND SURVEILLANCE DATA *** NIOSH OCCUPATIONAL EXPOSURE SURVEY DATA : NOHS - National Occupational Hazard Survey (1974) NOHS Hazard Code - 80058 No. of Facilities: 1115 (estimated) No. of Industries: 31 No. of Occupations: 32 No. of Employees: 13454 (estimated) NOES - National Occupational Exposure Survey (1983) NOES Hazard Code - 80058 No. of Facilities: 1082 (estimated) No. of Industries: 24 No. of Occupations: 23 No. of Employees: 25216 (estimated) No. of Female Employees: 7169 (estimated)
Safety Information
[ Symbol ]:
GHS07, GHS08
[ Signal Word ]:
Warning
[ Hazard Statements ]:
H319-H351
[ Precautionary Statements ]:
P305 + P351 + P338
[ Personal Protective Equipment ]:
dust mask type N95 (US);Eyeshields;Gloves
[ Hazard Codes ]:
Xn:Harmful;
[ Risk Phrases ]:
R22;R36/37/38;R40
[ Safety Phrases ]:
S26-S36/37-S45-S36/37/39
[ RIDADR ]:
2811
[ WGK Germany ]:
2
[ RTECS ]:
AJ0175000
[ Packaging Group ]:
II
[ Hazard Class ]:
8
[ HS Code ]:
29224995
Synthetic Route
Precursor & DownStream
Precursor
DownStream
Customs
[ HS Code ]: 2921199090
[ Summary ]:
2921199090 other acyclic monoamines and their derivatives; salts thereof VAT:17.0% Tax rebate rate:9.0% Supervision conditions:none MFN tariff:6.5% General tariff:30.0%
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