Chloroacetic acid
Names
[ CAS No. ]:
79-11-8
[ Name ]:
Chloroacetic acid
[Synonym ]:
Acetic acid,chloro
Monochloroethanoic acid
Acide chloracetique
2 chloroacetate
2-chloro acetic acid
Monochloressigsaeure
Chloracetic acid
Chloroethanoic acid
EINECS 201-178-4
MFCD00002683
chloroacetic acid
Chloroacetic acid,solid
Chemical & Physical Properties
[ Density]:
1.4±0.1 g/cm3
[ Boiling Point ]:
189.0±0.0 °C at 760 mmHg
[ Melting Point ]:
61 °C
[ Molecular Formula ]:
C2H3ClO2
[ Molecular Weight ]:
94.497
[ Flash Point ]:
71.5±19.8 °C
[ Exact Mass ]:
93.982155
[ PSA ]:
37.30000
[ LogP ]:
-0.05
[ Vapour density ]:
3.26 (vs air)
[ Vapour Pressure ]:
0.3±0.7 mmHg at 25°C
[ Index of Refraction ]:
1.438
[ Stability ]:
Stable. Deliquescent. Incompatible with strong bases, alkalies, most common metals, strong oxidizing agents.
[ Water Solubility ]:
SOLUBLE
MSDS
Toxicological Information
CHEMICAL IDENTIFICATION
- RTECS NUMBER :
- AF8575000
- CHEMICAL NAME :
- Acetic acid, chloro-
- CAS REGISTRY NUMBER :
- 79-11-8
- BEILSTEIN REFERENCE NO. :
- 0605438
- LAST UPDATED :
- 199710
- DATA ITEMS CITED :
- 25
- MOLECULAR FORMULA :
- C2-H3-Cl-O2
- MOLECULAR WEIGHT :
- 94.50
- WISWESSER LINE NOTATION :
- QV1G
HEALTH HAZARD DATA
ACUTE TOXICITY DATA
- TYPE OF TEST :
- LD50 - Lethal dose, 50 percent kill
- ROUTE OF EXPOSURE :
- Oral
- SPECIES OBSERVED :
- Rodent - rat
- DOSE/DURATION :
- 55 mg/kg
- TOXIC EFFECTS :
- Details of toxic effects not reported other than lethal dose value
- TYPE OF TEST :
- LC50 - Lethal concentration, 50 percent kill
- ROUTE OF EXPOSURE :
- Inhalation
- SPECIES OBSERVED :
- Rodent - rat
- DOSE/DURATION :
- 180 mg/m3
- TOXIC EFFECTS :
- Details of toxic effects not reported other than lethal dose value
- TYPE OF TEST :
- LD50 - Lethal dose, 50 percent kill
- ROUTE OF EXPOSURE :
- Intraperitoneal
- SPECIES OBSERVED :
- Rodent - rat
- DOSE/DURATION :
- 16600 ug/kg
- TOXIC EFFECTS :
- Details of toxic effects not reported other than lethal dose value
- TYPE OF TEST :
- LD50 - Lethal dose, 50 percent kill
- ROUTE OF EXPOSURE :
- Subcutaneous
- SPECIES OBSERVED :
- Rodent - rat
- DOSE/DURATION :
- 5 mg/kg
- TOXIC EFFECTS :
- Details of toxic effects not reported other than lethal dose value
- TYPE OF TEST :
- LD50 - Lethal dose, 50 percent kill
- ROUTE OF EXPOSURE :
- Subcutaneous
- SPECIES OBSERVED :
- Rodent - mouse
- DOSE/DURATION :
- 250 mg/kg
- TOXIC EFFECTS :
- Details of toxic effects not reported other than lethal dose value
- TYPE OF TEST :
- TDLo - Lowest published toxic dose
- ROUTE OF EXPOSURE :
- Oral
- SPECIES OBSERVED :
- Rodent - rat
- DOSE/DURATION :
- 9750 mg/kg/13W-I
- TOXIC EFFECTS :
- Cardiac - other changes Blood - changes in erythrocyte (RBC) count Related to Chronic Data - death
- TYPE OF TEST :
- TCLo - Lowest published toxic concentration
- ROUTE OF EXPOSURE :
- Inhalation
- SPECIES OBSERVED :
- Rodent - rat
- DOSE/DURATION :
- 20800 ug/m3/17W-I
- TOXIC EFFECTS :
- Kidney, Ureter, Bladder - other changes Blood - pigmented or nucleated red blood cells
- TYPE OF TEST :
- TDLo - Lowest published toxic dose
- ROUTE OF EXPOSURE :
- Oral
- SPECIES OBSERVED :
- Rodent - mouse
- DOSE/DURATION :
- 13 gm/kg/13W-I
- TOXIC EFFECTS :
- Liver - other changes Liver - changes in liver weight Related to Chronic Data - death
- TYPE OF TEST :
- TDLo - Lowest published toxic dose
- ROUTE OF EXPOSURE :
- Oral
- SPECIES OBSERVED :
- Rodent - mouse
- DOSE/DURATION :
- 3840 mg/kg/16D-I
- TOXIC EFFECTS :
- Sense Organs and Special Senses (Eye) - lacrimation Behavioral - ataxia Related to Chronic Data - death
- TYPE OF TEST :
- TCLo - Lowest published toxic concentration
- ROUTE OF EXPOSURE :
- Inhalation
- SPECIES OBSERVED :
- Rodent - guinea pig
- DOSE/DURATION :
- 20800 ug/m3/17W-I
- TOXIC EFFECTS :
- Kidney, Ureter, Bladder - other changes Blood - pigmented or nucleated red blood cells
- TYPE OF TEST :
- TDLo - Lowest published toxic dose
- ROUTE OF EXPOSURE :
- Subcutaneous
- SPECIES OBSERVED :
- Rodent - mouse
- DOSE/DURATION :
- 100 mg/kg
- TOXIC EFFECTS :
- Tumorigenic - equivocal tumorigenic agent by RTECS criteria Lungs, Thorax, or Respiration - tumors Liver - tumors
- TYPE OF TEST :
- TD - Toxic dose (other than lowest)
- ROUTE OF EXPOSURE :
- Subcutaneous
- SPECIES OBSERVED :
- Rodent - mouse
- DOSE/DURATION :
- 1300 mg/kg/65W-I
- TOXIC EFFECTS :
- Tumorigenic - equivocal tumorigenic agent by RTECS criteria Tumorigenic - tumors at site of application
MUTATION DATA
- TYPE OF TEST :
- Sister chromatid exchange
- TEST SYSTEM :
- Rodent - hamster Ovary
- DOSE/DURATION :
- 160 mg/L
- REFERENCE :
- EMMUEG Environmental and Molecular Mutagenesis. (Alan R. Liss, Inc., 41 E. 11th St., New York, NY 10003) V.10- 1987- Volume(issue)/page/year: 10(Suppl 10),1,1987 *** REVIEWS *** TOXICOLOGY REVIEW APTOA6 Acta Pharmacologica et Toxicologica. (Copenhagen, Denmark) V.1-59, 1945-86. For publisher information, see PHTOEH Volume(issue)/page/year: 11,13,1955 *** OCCUPATIONAL EXPOSURE LIMITS *** OEL-RUSSIA:STEL 1 mg/m3 JAN 1993 OEL-UNITED KINGDOM:TWA 0.3 ppm;STEL 1 ppm;Skin JAN 1993 *** NIOSH STANDARDS DEVELOPMENT AND SURVEILLANCE DATA *** NIOSH OCCUPATIONAL EXPOSURE SURVEY DATA : NOHS - National Occupational Hazard Survey (1974) NOHS Hazard Code - 18070 No. of Facilities: 1196 (estimated) No. of Industries: 9 No. of Occupations: 14 No. of Employees: 4726 (estimated) NOES - National Occupational Exposure Survey (1983) NOES Hazard Code - 18070 No. of Facilities: 265 (estimated) No. of Industries: 12 No. of Occupations: 20 No. of Employees: 10912 (estimated) No. of Female Employees: 1723 (estimated)
Safety Information
[ Symbol ]:
GHS02, GHS07
[ Signal Word ]:
Danger
[ Hazard Statements ]:
H225-H315
[ Precautionary Statements ]:
P210-P403 + P235
[ Personal Protective Equipment ]:
Eyeshields;full-face respirator (US);Gloves;multi-purpose combination respirator cartridge (US);type ABEK (EN14387) respirator filter
[ Hazard Codes ]:
T:Toxic
[ Risk Phrases ]:
R25;R34;R50
[ Safety Phrases ]:
S23-S37-S45-S61-S36-S26-S16
[ RIDADR ]:
UN 1751 6.1/PG 2
[ WGK Germany ]:
2
[ RTECS ]:
AF8575000
[ Packaging Group ]:
II
[ Hazard Class ]:
6.1
[ HS Code ]:
29154000
Synthetic Route
Precursor & DownStream
Precursor
DownStream
Customs
[ HS Code ]: 29154000
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