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ML-167

Names

[ CAS No. ]:
1285702-20-6

[ Name ]:
ML-167

[Synonym ]:
[5-(4-{[(5-Methyl-2-furyl)methyl]amino}-6-quinazolinyl)-2-furyl]methanol
2-Furanmethanol, 5-[4-[[(5-methyl-2-furanyl)methyl]amino]-6-quinazolinyl]-
[5-[4-[methyl-(5-methylfuran-2-yl)amino]quinazolin-6-yl]furan-2-yl]methanol
ML167

Biological Activity

[Description]:

ML167 is a highly selective Cdc2-like kinase 4 (Clk4) inhibitor with IC50 of 136 nM, >10-fold selectivity for closely related kinases Clk1, Clk2, Clk3 and Dyrk1A/1B.

[Related Catalog]:

Research Areas >> Cancer

[Target]

Clk4:136 nM (IC50)

CLK1:1522 nM (IC50)

Clk2:1648 nM (IC50)

Dyrk1B:4420 nM (IC50)


[References]

[1]. Rosenthal AS, et al. An inhibitor of the Cdc2-like kinase 4 (Clk4).


[Related Small Molecules]

Abemaciclib(LY2835219) | Ribociclib (LEE011) | Dinaciclib (SCH727965) | THZ1 2HCl | Roscovitine (CYC202) | THZ531 | RO-3306 | Flavopiridol | NVP 2 | BAY-1143572 Racemate | CYC-065 | AZD5438 | BIO | Kenpaullone | SNS-032 (BMS-387032)

Chemical & Physical Properties

[ Density]:
1.3±0.1 g/cm3

[ Boiling Point ]:
531.8±45.0 °C at 760 mmHg

[ Molecular Formula ]:
C19H17N3O3

[ Molecular Weight ]:
335.357

[ Flash Point ]:
275.4±28.7 °C

[ Exact Mass ]:
335.126984

[ PSA ]:
75.53000

[ LogP ]:
2.68

[ Appearance of Characters ]:
off-white to gray to brown

[ Vapour Pressure ]:
0.0±1.5 mmHg at 25°C

[ Index of Refraction ]:
1.679

[ Storage condition ]:
?20°C

[ Water Solubility ]:
DMSO: soluble10mg/mL, clear

MSDS

Click to get detail MSDS

Safety Information

[ Symbol ]:

GHS07

[ Signal Word ]:
Warning

[ Hazard Statements ]:
H302

[ Hazard Codes ]:
Xn

[ Risk Phrases ]:
22

[ Safety Phrases ]:
46

[ RIDADR ]:
NONH for all modes of transport

Related Compounds

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