ML 418

Names

[ CAS No. ]:
1928763-08-9

[ Name ]:
ML 418

[Synonym ]:
MFCD32201056

Biological Activity

[Description]:

ML418 is the first potent, selective and CNS penetrating blocker of Kir7.1 potassium channel (IC50, 310 nM), which also potently inhibits Kir6.2/SUR1, and exhibits superior selectivity over other Kir channels[1].

[Related Catalog]:

Research Areas >> Others

Signaling Pathways >> Membrane Transporter/Ion Channel >> Potassium Channel

[References]

[1]. ML418, et al. ML418: The First Selective, Sub-Micromolar Pore Blocker of Kir7.1 Potassium Channels. ACS Chem Neurosci. 2016 Jul 20;7(7):1013-23.

Chemical & Physical Properties

[ Molecular Formula ]:
C₁₉H₂₄ClN₃O₃

[ Molecular Weight ]:
377.87

[ Storage condition ]:
-20°C

Related Compounds

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