spermidine

Names

[ CAS No. ]:
124-20-9

[ Name ]:
spermidine

[Synonym ]:
spermidine
N-(γ-aminopropyl)tetramethylenediamine
N-(3-Aminopropyl)butan-1,4-diamin
N'-(3-aminopropyl)butane-1,4-diamine
1,8-Diamino-4-azaoctane (N-(3-Aminopropyl)-1,4-diaminobutane
Additive Screening
N1-(3-Aminopropyl)butane-1,4-diamine
N-(3-Aminopropyl)-4-aminobutylamine
N-(3-Aminopropyl)butane-1,4-diamine
MFCD00008229
1,4-Butanediamine, N-(3-aminopropyl)-
N-(3-Aminopropyl)-1,4-butanediamine
N-(g-Aminopropyl)tetramethylenediamine
EINECS 204-689-0

Biological Activity

[Description]:

Spermidine, a precursor of spermine, is a polyamine derived from putrescine and could help stabilize some membranes and nucleic acid structures.

[Related Catalog]:

Research Areas >> Metabolic Disease

Natural Products >> Others

[Target]

Human Endogenous Metabolite

[Related Small Molecules]

Chemical & Physical Properties

[ Density]:
0.9±0.1 g/cm3

[ Boiling Point ]:
246.6±8.0 °C at 760 mmHg

[ Melting Point ]:
23-25 °C

[ Molecular Formula ]:
C₇H₁₉N₃

[ Molecular Weight ]:
145.246

[ Flash Point ]:
118.1±22.0 °C

[ Exact Mass ]:
145.157898

[ PSA ]:
64.07000

[ LogP ]:
-0.84

[ Vapour Pressure ]:
0.0±0.5 mmHg at 25°C

[ Index of Refraction ]:
1.475

[ Storage condition ]:
2-8°C

[ Stability ]:
Stable, but air-sensitive and very hygroscopic - store under argon. Incompatible with acids, acid chlorides, acid anhydrides, oxidizing agents.

[ Water Solubility ]:
H2O: 1 M at 20 °C, clear, colorless

MSDS

Click to get detail MSDS

Toxicological Information

CHEMICAL IDENTIFICATION

RTECS NUMBER :: EJ7000000

CHEMICAL NAME :: 1,4-Butanediamine, N-(3-aminopropyl)-

CAS REGISTRY NUMBER :: 124-20-9

BEILSTEIN REFERENCE NO. :: 1698591

LAST UPDATED :: 199706

DATA ITEMS CITED :: 12

MOLECULAR FORMULA :: C7-H19-N3

MOLECULAR WEIGHT :: 145.29

WISWESSER LINE NOTATION :: Z4M3Z

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

TYPE OF TEST :: LD30 - Lethal Dose

ROUTE OF EXPOSURE :: Oral

SPECIES OBSERVED :: Rodent - mouse

DOSE/DURATION :: >1 gm/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

TYPE OF TEST :: LD30 - Lethal Dose

ROUTE OF EXPOSURE :: Subcutaneous

SPECIES OBSERVED :: Rodent - mouse

DOSE/DURATION :: 450 mg/kg

TOXIC EFFECTS :: Behavioral - somnolence (general depressed activity) Behavioral - convulsions or effect on seizure threshold Nutritional and Gross Metabolic - body temperature decrease

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Intravenous

SPECIES OBSERVED :: Rodent - mouse

DOSE/DURATION :: 78 mg/kg

TOXIC EFFECTS :: Behavioral - convulsions or effect on seizure threshold Lungs, Thorax, or Respiration - respiratory depression

TYPE OF TEST :: TDLo - Lowest published toxic dose

ROUTE OF EXPOSURE :: Oral

SPECIES OBSERVED :: Bird - chicken

DOSE/DURATION :: 9504 gm/kg/14D-C

TOXIC EFFECTS :: Behavioral - food intake (animal) Liver - other changes Nutritional and Gross Metabolic - weight loss or decreased weight gain

MUTATION DATA

TYPE OF TEST :: DNA damage

TEST SYSTEM :: Mammal - species unspecified Lung

DOSE/DURATION :: 200 mmol/L

REFERENCE :: IJRBA3 International Journal of Radiation Biology and Related Studies in Physics, Chemistry and Medicine. (Taylor & Francis Inc., 242 Cherry St., Philadelphia, PA 19106) V.1- 1959- Volume(issue)/page/year: 9,185,1965

Safety Information

[ Symbol ]:

GHS05

[ Signal Word ]:
Danger

[ Hazard Statements ]:
H314

[ Precautionary Statements ]:
P280-P305 + P351 + P338-P310

[ Personal Protective Equipment ]:
Faceshields;full-face respirator (US);Gloves;Goggles;multi-purpose combination respirator cartridge (US);type ABEK (EN14387) respirator filter

[ Hazard Codes ]:
C:Corrosive;

[ Risk Phrases ]:
R34

[ Safety Phrases ]:
S26-S36/37/39-S45

[ RIDADR ]:
UN 2735 8/PG 2

[ WGK Germany ]:
3

[ RTECS ]:
EJ7000000

[ Packaging Group ]:
III

[ Hazard Class ]:
8

[ HS Code ]:
2921290000

Synthetic Route

Click to get detail synthetic route

Precursor & DownStream

Precursor

DownStream

Customs

[ HS Code ]: 2921290000

[ Summary ]:
2921290000 other acyclic polyamines and their derivatives; salts thereof。Supervision conditions:None。VAT:17.0%。Tax rebate rate:9.0%。MFN tariff:6.5%。General tariff:30.0%

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