N-acetylspermine

Names

[ Name ]:
N-acetylspermine

[Synonym ]:
N-[3-[4-(3-aminopropylamino)butylamino]propyl]acetamide
n-[3-({4-[(3-aminopropyl)amino]butyl}amino)propyl]acetamid
N'-Monoacetylspermine
N(1)-acetylspermine
N-Acetylspermine
N(1)-Acetylspermine

Biological Activity

[Description]:

N1-Acetylspermine is an endogenous metabolite present in Urine that can be used for the research of Leukemia[1][2].

[Related Catalog]:

Research Areas >> Cancer

[Target]

Human Endogenous Metabolite

[In Vitro]

Endogenous metabolites is defined as those that are annotated by Kyoto Encyclopedia of Genes and Genomes as substrates or products of the ~1900 metabolic enzymes encoded in our genome. It is clear in the body of literature that there are documented toxic properties for many of these metabolites[1].

[References]

[1]. Lee N, et al. Endogenous toxic metabolites and implications in cancer therapy. Oncogene. 2020 Aug;39(35):5709-5720.

[2]. Lee SH, et al. Polyamine profiles in the urine of patients with leukemia. Cancer Lett. 1998 Jan 9;122(1-2):1-8.

Chemical & Physical Properties

[ Density]:
0.962g/cm3

[ Boiling Point ]:
442.9ºC at 760 mmHg

[ Molecular Formula ]:
C₁₂H₂₈N₄O

[ Molecular Weight ]:
244.37700

[ Flash Point ]:
221.7ºC

[ Exact Mass ]:
244.22600

[ PSA ]:
82.67000

[ LogP ]:
2.14320

[ Vapour Pressure ]:
4.84E-08mmHg at 25°C

[ Index of Refraction ]:
1.479

Safety Information

[ Hazard Codes ]:
Xi

[ Risk Phrases ]:
36/37/38

[ Safety Phrases ]:
26-36

[ HS Code ]:
2924199090

Synthetic Route

Click to get detail synthetic route

Precursor & DownStream

Precursor

DownStream

Customs

[ HS Code ]: 2924199090

[ Summary ]:
2924199090. other acyclic amides (including acyclic carbamates) and their derivatives; salts thereof. VAT:17.0%. Tax rebate rate:13.0%. . MFN tariff:6.5%. General tariff:30.0%