Felbamate hydrate
Names
[ CAS No. ]:
1177501-39-1
[ Name ]:
Felbamate hydrate
[Synonym ]:
2-Phenyl-1,3-propanediyl dicarbamate hydrate (1:1)
1,3-Propanediol, 2-phenyl-, dicarbamate, hydrate (1:1)
MFCD28168059
Biological Activity
[Description]:
Felbamate hydrate (FBM) is a potent nonsedative anticonvulsant whose clinical effect may be related to the inhibition of N-methyl-D-aspartate (NMDA) .Target: NMDA ReceptorFelbamate (marketed under the brand name Felbatol by MedPointe) is an anti-epileptic drug used in the treatment of epilepsy. It is used to treat partial seizures (with and without generalization) in adults and partial and generalized seizures associated with Lennox-Gastaut syndrome in children. However, an increased risk of potentially fatal aplastic anemia and/or liver failure limit the drugs usage to severe refractory epilepsy.Felbamate has been proposed to a unique dual mechanism of action as a positive modulator of GABAA receptors and as a blocker of NMDA receptors, particularly isoforms containing the NR2B subunit. Although it is clear that felbamate does cause pharmacological inhibition of NMDA receptor of relevance of NMDA receptor blockade as a strategy for the treatment of human epilepsy has been questioned. Therefore, the importance of the effects of felbamate on NMDA receptors to its therapeutic action in epilepsy is uncertain.
[Related Catalog]:
[References]
[Related Small Molecules]
Chemical & Physical Properties
[ Molecular Formula ]:
C11H16N2O5
[ Molecular Weight ]:
256.255
[ Exact Mass ]:
256.105927
[ Storage condition ]:
2-8℃