beta-Alanine

Names

[ CAS No. ]:
107-95-9

[ Name ]:
beta-Alanine

[Synonym ]:
3-Aminopropanoic acid
beta-alanine
3-Aminopropionic Acid
EINECS 203-536-5
MFCD00008200
β-Alanine
H-β-Ala-OH

Biological Activity

[Description]:

β-Alanine is a non-essential amino acid that is shown to be metabolized into carnosine, which functions as an intracellular buffer.

[Related Catalog]:

Natural Products >> Others

Research Areas >> Metabolic Disease

[Target]

Human Endogenous Metabolite

[In Vitro]

Cells treated with β-alanine display significantly suppressed basal and peak ECAR (aerobic glycolysis), with simultaneous increase in glucose transporter 1 (GLUT1). Additionally, cells treated with β-alanine exhibit significantly reduced basal and peak OCR (oxidative metabolism), which is accompanied by reduction in mitochondrial content with subsequent suppression of genes which promote mitochondrial biosynthesis. Suppression of glycolytic and oxidative metabolism by β-alanine results in the reduction of total metabolic rate, although cell viability is not affected.β-alanine is shown to reduce both cell migration and proliferation without acting in a cytotoxic fashion. Moreover, β-alanine significantly increases malignant cell sensitivity to doxorubicin, suggesting a potential role as a co-therapeutic agent[1].

[References]

[1]. Vaughan RA, et al. β-alanine suppresses malignant breast epithelial cell aggressiveness through alterations in metabolism and cellular acidity in vitro. Mol Cancer. 2014 Jan 24;13:14.

[Related Small Molecules]

Chemical & Physical Properties

[ Density]:
1.2±0.1 g/cm3

[ Boiling Point ]:
237.1±23.0 °C at 760 mmHg

[ Melting Point ]:
202 °C (dec.)(lit.)

[ Molecular Formula ]:
C₃H₇NO₂

[ Molecular Weight ]:
89.093

[ Flash Point ]:
97.2±22.6 °C

[ Exact Mass ]:
89.047676

[ PSA ]:
63.32000

[ LogP ]:
-0.86

[ Vapour Pressure ]:
0.0±1.0 mmHg at 25°C

[ Index of Refraction ]:
1.463

[ Storage condition ]:
Store at RT.

[ Water Solubility ]:
H2O: 1 M at 20 °C, clear, colorless

MSDS

Click to get detail MSDS

Safety Information

[ Personal Protective Equipment ]:
Eyeshields;Gloves;type N95 (US);type P1 (EN143) respirator filter

[ Hazard Codes ]:
Xi

[ Risk Phrases ]:
R36/37/38

[ Safety Phrases ]:
S24/25

[ RIDADR ]:
NONH for all modes of transport

[ WGK Germany ]:
3

[ RTECS ]:
UA2369200

[ HS Code ]:
29224920

Synthetic Route

Click to get detail synthetic route

Precursor & DownStream

Precursor

DownStream

Customs

[ HS Code ]: 2922499990

[ Summary ]:
HS:2922499990 other amino-acids, other than those containing more than one kind of oxygen function, and their esters; salts thereof VAT:17.0% Tax rebate rate:9.0% Supervision conditions:AB(certificate of inspection for goods inward,certificate of inspection for goods outward) MFN tariff:6.5% General tariff:30.0%

Articles

Metabolomic profiles delineate potential role for sarcosine in prostate cancer progression.

Nature 457(7231) , 910-4, (2009)

Multiple, complex molecular events characterize cancer development and progression. Deciphering the molecular networks that distinguish organ-confined disease from metastatic disease may lead to the i...

Automated screening of urine samples for carbohydrates, organic and amino acids after treatment with urease.

J. Chromatogr. A. 562(1-2) , 125-38, (1991)

Eighty-five clinical urine samples and nineteen urine samples previously found by other laboratories to suggest genetic metabolic defects were prepared for trimethylsilylation by treatment with urease...

Urinary and plasma organic acids and amino acids in chronic fatigue syndrome.

Clin. Chim. Acta 361(1-2) , 150-8, (2005)

Previous work by others have suggested the occurrence of one or more chemical or metabolic 'markers' for ME/CFS including specific amino acids and organic acids and a number of unidentified compounds ...