N-Succinimidyl 3-maleimidopropionate

Names

[ Name ]:
N-Succinimidyl 3-maleimidopropionate

[Synonym ]:
1-{3-[(2,5-Dioxo-1-pyrrolidinyl)oxy]-3-oxopropyl}-1H-pyrrole-2,5-dione
(2,5-dioxopyrrolidin-1-yl) 3-(2,5-dioxopyrrol-1-yl)propanoate
1-{3-[(2,5-Dioxopyrrolidin-1-yl)oxy]-3-oxopropyl}-1H-pyrrole-2,5-dione
MFCD00043141
1H-pyrrole-2,5-dione, 1-[3-[(2,5-dioxo-1-pyrrolidinyl)oxy]-3-oxopropyl]-

Biological Activity

[Description]:

BMPS is a nonclaevable ADC linker used in the synthesis of antibody-drug conjugates (ADCs).

[Related Catalog]:

Research Areas >> Cancer

Signaling Pathways >> Antibody-drug Conjugate >> ADC Linker

[Target]

Noncleavable

Chemical & Physical Properties

[ Density]:
1.55g/cm3

[ Boiling Point ]:
448.8ºC at 760mmHg

[ Melting Point ]:
168-170 °C(lit.)

[ Molecular Formula ]:
C₁₁H₁₀N₂O₆

[ Molecular Weight ]:
266.20700

[ Flash Point ]:
225.2ºC

[ Exact Mass ]:
266.05400

[ PSA ]:
101.06000

[ Index of Refraction ]:
1.605

[ Storage condition ]:
2-8°C

MSDS

Click to get detail MSDS

Safety Information

[ Symbol ]:

GHS07

[ Signal Word ]:
Warning

[ Hazard Statements ]:
H335

[ Precautionary Statements ]:
P261

[ Personal Protective Equipment ]:
dust mask type N95 (US);Eyeshields;Gloves

[ Hazard Codes ]:
Xi:Irritant;

[ Risk Phrases ]:
R37

[ Safety Phrases ]:
S26-S36/37/39

[ RIDADR ]:
NONH for all modes of transport

[ WGK Germany ]:
3

[ HS Code ]:
2925190090

Synthetic Route

Click to get detail synthetic route

Precursor & DownStream

Precursor

DownStream

Customs

[ HS Code ]: 2925190090

[ Summary ]:
2925190090 other imides and their derivatives; salts thereof VAT:17.0% Tax rebate rate:9.0% Supervision conditions:none MFN tariff:6.5% General tariff:30.0%

Articles

Nanobody-functionalized PEG-b-PCL polymersomes and their targeting study.

J. Biotechnol. 214 , 147-55, (2015)

We prepared and characterized polymersomes functionalized with nanobodies (VHHs) on the basis of biocompatible, biodegradable and FDA-approved poly(ethylene glycol)-block-poly(ϵ-caprolactone) (PEG-b-P...

Immobilization of the cell-adhesive peptide Arg-Gly-Asp-Cys (RGDC) on titanium surfaces by covalent chemical attachment.

J. Mater. Sci. Mater. Med. 8 , 867-872, (1997)

Surface modification of acid-pretreated titanium with 3-aminopropyltriethoxylsilane (APTES) in dry toluene resulted in covalently bonded siloxane films with surface coverage that was relatively contro...

Covalent attachment of functionalized lipid bilayers to planar waveguides for measuring protein binding to biomimetic membranes.

Protein Sci. 4 , 2532-2544, (1995)

A new method is presented for measuring sensitively the interactions between ligands and their membrane-bound receptors in situ using integrated optics, thus avoiding the need for additional labels. P...