N-SUCCINIMIDYL 3-(BROMOACETAMIDO)PROPIONATE

Names

[ Name ]:
N-SUCCINIMIDYL 3-(BROMOACETAMIDO)PROPIONATE

[Synonym ]:
(2,5-dioxopyrrolidin-1-yl) 3-[(2-bromoacetyl)amino]propanoate

Biological Activity

[Description]:

N-Succinimidyl 3-(Bromoacetamido)propionate is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs[1]. N-Succinimidyl 3-(Bromoacetamido)propionate is also a cleavable ADC linker used in the synthesis of antibody-drug conjugates (ADCs)[2].

[Related Catalog]:

Research Areas >> Cancer

Signaling Pathways >> Antibody-drug Conjugate >> ADC Linker

Signaling Pathways >> PROTAC >> PROTAC Linker

[Target]

PEGs

Alkyl/ether

Cleavable

[In Vitro]

PROTACs contain two different ligands connected by a linker; one is a ligand for an E3 ubiquitin ligase and the other is for the target protein. PROTACs exploit the intracellular ubiquitin-proteasome system to selectively degrade target proteins[1]. ADCs are comprised of an antibody to which is attached an ADC cytotoxin through an ADC linker[2].

[References]

[1]. An S, et al. Small-molecule PROTACs: An emerging and promising approach for the development of targeted therapy drugs. EBioMedicine. 2018 Oct;36:553-562.

[2]. Beck A, et al. Strategies and challenges for the next generation of antibody-drug conjugates. Nat Rev Drug Discov. 2017 May;16(5):315-337.

Chemical & Physical Properties

[ Density]:
1.69 g/cm3

[ Melting Point ]:
93-94ºC

[ Molecular Formula ]:
C₉H₁₁BrN₂O₅

[ Molecular Weight ]:
307.09800

[ Exact Mass ]:
305.98500

[ PSA ]:
92.78000

[ Index of Refraction ]:
1.566

Safety Information

[ Hazard Codes ]:
Xi

[ HS Code ]:
2925190090

Synthetic Route

Click to get detail synthetic route

Precursor & DownStream

Precursor

DownStream

Customs

[ HS Code ]: 2925190090

[ Summary ]:
2925190090 other imides and their derivatives; salts thereof VAT:17.0% Tax rebate rate:9.0% Supervision conditions:none MFN tariff:6.5% General tariff:30.0%