N-Bromoacetyl-β-alanine

Names

[ Name ]:
N-Bromoacetyl-β-alanine

[Synonym ]:
N-Bromoacetyl-|A-alanine

Biological Activity

[Description]:

N-Bromoacetyl-β-alanine is an alkyl chain-based PROTAC linker that can be used in the synthesis of PROTACs[1]. N-Bromoacetyl-β-alanine is also a cleavable ADC linker used in the synthesis of antibody-drug conjugates (ADCs)[2].

[Related Catalog]:

Research Areas >> Cancer

Signaling Pathways >> Antibody-drug Conjugate >> ADC Linker

Signaling Pathways >> PROTAC >> PROTAC Linker

[Target]

Alkyl-Chain

Cleavable

[In Vitro]

PROTACs contain two different ligands connected by a linker; one is a ligand for an E3 ubiquitin ligase and the other is for the target protein. PROTACs exploit the intracellular ubiquitin-proteasome system to selectively degrade target proteins[1]. ADCs are comprised of an antibody to which is attached an ADC cytotoxin through an ADC linker[2].

[References]

[1]. An S, et al. Small-molecule PROTACs: An emerging and promising approach for the development of targeted therapy drugs. EBioMedicine. 2018 Oct;36:553-562.

[2]. Beck A, et al. Strategies and challenges for the next generation of antibody-drug conjugates. Nat Rev Drug Discov. 2017 May;16(5):315-337.

Chemical & Physical Properties

[ Density]:
1.682g/cm3

[ Boiling Point ]:
433.4ºC at 760 mmHg

[ Molecular Formula ]:
C₅H₈BrNO₃

[ Molecular Weight ]:
210.02600

[ Flash Point ]:
215.9ºC

[ Exact Mass ]:
208.96900

[ PSA ]:
69.89000

[ LogP ]:
0.81250

[ Index of Refraction ]:
1.523

Safety Information

[ Hazard Codes ]:
Xi

Synthetic Route

Click to get detail synthetic route

Precursor & DownStream

Precursor

DownStream

Related Compounds

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