57159-62-3

57159-62-3 structure

Name: N-SUCCINIMIDYL 3-(BROMOACETAMIDO)PROPIONATE
Chemical Name: N-Succinimidyl 3-(Bromoacetamido)propionate
CAS Number: 57159-62-3
Molecular Formula: C₉H₁₁BrN₂O₅
Molecular Weight: 307.09800
Catalog: Signaling Pathways Antibody-drug Conjugate ADC Linker
Create Date: 2018-11-22 10:32:40
Modify Date: 2025-08-25 11:26:50
N-Succinimidyl 3-(Bromoacetamido)propionate is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs[1]. N-Succinimidyl 3-(Bromoacetamido)propionate is also a cleavable ADC linker used in the synthesis of antibody-drug conjugates (ADCs)[2].

Name	N-Succinimidyl 3-(Bromoacetamido)propionate
Synonyms	(2,5-dioxopyrrolidin-1-yl) 3-[(2-bromoacetyl)amino]propanoate

Description	N-Succinimidyl 3-(Bromoacetamido)propionate is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs[1]. N-Succinimidyl 3-(Bromoacetamido)propionate is also a cleavable ADC linker used in the synthesis of antibody-drug conjugates (ADCs)[2].
Related Catalog	Research Areas >> Cancer Signaling Pathways >> Antibody-drug Conjugate >> ADC Linker Signaling Pathways >> PROTAC >> PROTAC Linker
Target	PEGs Alkyl/ether Cleavable
In Vitro	PROTACs contain two different ligands connected by a linker; one is a ligand for an E3 ubiquitin ligase and the other is for the target protein. PROTACs exploit the intracellular ubiquitin-proteasome system to selectively degrade target proteins[1]. ADCs are comprised of an antibody to which is attached an ADC cytotoxin through an ADC linker[2].
References	[1]. An S, et al. Small-molecule PROTACs: An emerging and promising approach for the development of targeted therapy drugs. EBioMedicine. 2018 Oct;36:553-562. [2]. Beck A, et al. Strategies and challenges for the next generation of antibody-drug conjugates. Nat Rev Drug Discov. 2017 May;16(5):315-337.

Hazard Codes	Xi
HS Code	2925190090

6066-82-6

89520-11-6

~50%

57159-62-3

Literature: Zaitsu; Ohnishi; Hosoya; Sugimoto; Ohkura Chemical and pharmaceutical bulletin, 1987 , vol. 35, # 5 p. 1991 - 1997

Precursor 2
6066-82-6 89520-11-6
DownStream 0

HS Code	2925190090
Summary	2925190090 other imides and their derivatives; salts thereof VAT:17.0% Tax rebate rate:9.0% Supervision conditions:none MFN tariff:6.5% General tariff:30.0%