Monitoring neonatal fungal infection with metabolomics.

Angelica Dessì, Barbara Liori, Pierluigi Caboni, Giovanni Corsello, Mario Giuffrè, Antonio Noto, Francesca Serraino, Mauro Stronati, Marco Zaffanello, Vassilios Fanos

Index: J. Matern. Fetal. Neonatal. Med. 27 Suppl 2 , 34-8, (2014)

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Abstract

The objective of our study was to evaluate the capability of the metabolomics approach to identify the variations of urine metabolites over time related to the neonatal fungal septic condition. The study population included a clinical case of a preterm neonate with invasive fungal infection and 13 healthy preterm controls. This study showed a unique urine metabolic profile of the patient affected by fungal sepsis compared to urine of controls and it was also possible to evaluate the efficacy of therapy in improving patient health.