L-Threonine

Names

[ CAS No. ]:
72-19-5

[ Name ]:
L-Threonine

[Synonym ]:
EINECS 200-774-1
L-Tlhreonine
H-THR-OH
L-Threonine (JP15)
(2S,3R)-(-)-Threonine
L-α-Amino-β-hydroxybutyric acid
L-Threonine
2-Amino-3-hydroxybutanoic acid, (R-(R*,S*))-
UNII:TFM6DU5S6A
H-L-THR-OH
MFCD00063722
THR
(R-(R*,S*))-2-Amino-3-hydroxybutanoic acid
L-2-Amino-3-hydroxybutyric acid
Threonine
(2S,3R)-Threonine
[R-(R*,S*)]-2-Amino-3-hydroxybutanoic acid
MFCD00064270
(2S,3R)-2-Amino-3-hydroxybutyric acid
Butanoic acid, 2-amino-3-hydroxy-, (R-(R*,S*))-
QY1&YZVQ &&L or (2S,3R)- Form
(s)-threonine
l-threonin
(2S,3R)-2-Amino-3-hydroxybutanoic acid
l-Thr
Threonin

Biological Activity

[Description]:

L-Threonine is a natural amino acid, can be produced by microbial fermentation, and is used in food, medicine, or feed[1].

[Related Catalog]:

Research Areas >> Others

Signaling Pathways >> Others >> Others

[References]

[1]. Zhao H, et al. Increasing L-threonine production in Escherichia coli by engineering the glyoxylate shunt and the L-threonine biosynthesis pathway. Appl Microbiol Biotechnol. 2018 Jul;102(13):5505-5518.

Chemical & Physical Properties

[ Density]:
1.3±0.1 g/cm3

[ Boiling Point ]:
345.8±32.0 °C at 760 mmHg

[ Melting Point ]:
255ºC

[ Molecular Formula ]:
C₄H₉NO₃

[ Molecular Weight ]:
119.119

[ Flash Point ]:
162.9±25.1 °C

[ Exact Mass ]:
119.058243

[ PSA ]:
83.55000

[ LogP ]:
-1.23

[ Vapour Pressure ]:
0.0±1.7 mmHg at 25°C

[ Index of Refraction ]:
1.507

MSDS

Click to get detail MSDS

Toxicological Information

CHEMICAL IDENTIFICATION

RTECS NUMBER :: XO8590000

CHEMICAL NAME :: Threonine, L-

CAS REGISTRY NUMBER :: 72-19-5

LAST UPDATED :: 199709

DATA ITEMS CITED :: 5

MOLECULAR FORMULA :: C4-H9-N-O3

MOLECULAR WEIGHT :: 119.14

WISWESSER LINE NOTATION :: QY1&YZVQ -L

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Intraperitoneal

SPECIES OBSERVED :: Rodent - rat

DOSE/DURATION :: 3098 mg/kg

TOXIC EFFECTS :: Behavioral - muscle contraction or spasticity Lungs, Thorax, or Respiration - dyspnea Nutritional and Gross Metabolic - body temperature decrease

MUTATION DATA

TYPE OF TEST :: Sister chromatid exchange

TEST SYSTEM :: Human Lymphocyte

DOSE/DURATION :: 10 mg/L

REFERENCE :: MUREAV Mutation Research. (Elsevier Science Pub. B.V., POB 211, 1000 AE Amsterdam, Netherlands) V.1- 1964- Volume(issue)/page/year: 372,75,1996 *** NIOSH STANDARDS DEVELOPMENT AND SURVEILLANCE DATA *** NIOSH OCCUPATIONAL EXPOSURE SURVEY DATA : NOHS - National Occupational Hazard Survey (1974) NOHS Hazard Code - 81868 No. of Facilities: 53 (estimated) No. of Industries: 1 No. of Occupations: 3 No. of Employees: 750 (estimated) NOES - National Occupational Exposure Survey (1983) NOES Hazard Code - 81868 No. of Facilities: 787 (estimated) No. of Industries: 3 No. of Occupations: 13 No. of Employees: 18524 (estimated) No. of Female Employees: 13980 (estimated)

Safety Information

[ Personal Protective Equipment ]:
Eyeshields;Gloves;type N95 (US);type P1 (EN143) respirator filter

[ Hazard Codes ]:
Xi

[ Risk Phrases ]:
36/37/38

[ Safety Phrases ]:
S24/25

[ RIDADR ]:
NONH for all modes of transport

[ WGK Germany ]:
3

[ RTECS ]:
XO8590000

[ HS Code ]:
29225000

Synthetic Route

Click to get detail synthetic route

Precursor & DownStream

Precursor

DownStream

Customs

[ HS Code ]: 2922509090

[ Summary ]:
2922509090. other amino-alcohol-phenols, amino-acid-phenols and other amino-compounds with oxygen function. VAT:17.0%. Tax rebate rate:13.0%. . MFN tariff:6.5%. General tariff:30.0%

Articles

Urinary metabolic fingerprinting of mice with diet-induced metabolic derangements by parallel dual secondary column-dual detection two-dimensional comprehensive gas chromatography.

J. Chromatogr. A. 1361 , 265-76, (2014)

This study investigates the potential of a parallel dual secondary column-dual detection two-dimensional comprehensive GC platform (GC×2GC-MS/FID) for metabolic profiling and fingerprinting of mouse u...

Mechanism of chemical activation of sodium chloride in the presence of amino acids.

Food Chem. 166 , 301-8, (2014)

Sodium chloride has been shown to promote chlorination of glycerol during thermal processing. However, the detailed mechanism of this reaction is not well understood. Preliminary experiments have indi...

The unique serine/threonine phosphatase from the minimal bacterium Mycoplasma synoviae: biochemical characterization and metal dependence.

J. Biol. Inorg. Chem. 20(1) , 61-75, (2015)

Serine/threonine protein phosphatases have been described in many pathogenic bacteria as essential enzymes involved in phosphorylation-dependent signal transduction pathways and frequently associated ...