ALK5-IN-33

Modify Date: 2024-04-07 10:06:29

ALK5-IN-33 structure	Common Name	ALK5-IN-33
	CAS Number	2785430-89-7	Molecular Weight	413.48
	Density	N/A	Boiling Point	N/A
	Molecular Formula	C₂₃H₂₃N₇O	Melting Point	N/A
	MSDS	N/A	Flash Point	N/A

Use of ALK5-IN-33

ALK5-IN-33 (Compound EX-10) is a selective, orally active ALK-5 inhibitor with an IC50 ≤10 nM[1].

Name	ALK5-IN-33

Description	ALK5-IN-33 (Compound EX-10) is a selective, orally active ALK-5 inhibitor with an IC50 ≤10 nM[1].
Related Catalog	Research Areas >> Cancer
Target	ALK5:≤10 nM (IC50) ALK2
In Vitro	ALK-IN-33 (Compound EX-10) shows a high efficiency by inducing a full inhibition (max PIN greater than 75) of TGF-β1 mediated alpha-SMA expression, in at least two donors[1].
In Vivo	ALK-IN-33 (Compound EX-10) (10-100 mg/kg; i.g.; once) reduces the phospho SMAD2 levels in a dose dependent fashion in A549 xenograft model in mice[1]. Animal Model: Female athymic nude mice, A549 xenograft model[1] Dosage: 10, 50, 75 and 100 mg/kg Administration: Oral gavage, once Result: Reduced the phospho SMAD2 levels (p-SMAD2) in a dose dependent fashion.
References	[1]. Bettina FRANZ, et al. Alk-5 inhibitors and uses thereof. Patent WO2022126133A1.

Molecular Formula	C₂₃H₂₃N₇O
Molecular Weight	413.48