HDAC6 degrader-3
Modify Date: 2024-04-12 09:52:03
HDAC6 degrader-3 structure
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Common Name | HDAC6 degrader-3 | ||
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| CAS Number | 2785404-83-1 | Molecular Weight | 883.80 | |
| Density | N/A | Boiling Point | N/A | |
| Molecular Formula | C41H41F4N7O11 | Melting Point | N/A | |
| MSDS | N/A | Flash Point | N/A | |
Use of HDAC6 degrader-3HDAC6 degrader-3 is a potent and selective HDAC6 degrader via ternary complex formation and the ubiquitin-proteasome pathway with a DC50 value of 19.4 nM. HDAC6 degrader-3 has IC50s of 4.54 nM and 0.647 μM for HDAC6 and HDAC1, respectively. HDAC6 degrader-3 causes strong hyperacetylation of α-tubulin[1]. |
| Name | HDAC6 degrader-3 |
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| Description | HDAC6 degrader-3 is a potent and selective HDAC6 degrader via ternary complex formation and the ubiquitin-proteasome pathway with a DC50 value of 19.4 nM. HDAC6 degrader-3 has IC50s of 4.54 nM and 0.647 μM for HDAC6 and HDAC1, respectively. HDAC6 degrader-3 causes strong hyperacetylation of α-tubulin[1]. |
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| Related Catalog | |
| Target |
HDAC6:19.4 nM (ID50) HDAC6:4.54 nM (IC50) HDAC1:0.647 μM (IC50) Cereblon |
| In Vitro | HDAC6 degrader-3 (化合物 B4; 100-1000 nM; 24 小时) 表现出有效的 HDAC6 降解以及 α-微管蛋白的高度乙酰化[1]。 HDAC6 degrader-3 (0.5-50 μM; 72 小时) 对白血病细胞系 (697、HL-60、KASUMI-1、MV4-11、REH、THP-1、SKNO- 1, MOLM-13)[1]。 Western Blot Analysis[1] Cell Line: U266 multiple myeloma cell line Concentration: 100 nM and 1000 nM Incubation Time: 24 h Result: Demonstrated potent HDAC6 degradation as well as hyperacetylation of α-tubulin. |
| References |
| Molecular Formula | C41H41F4N7O11 |
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| Molecular Weight | 883.80 |