2079056-43-0

2079056-43-0 structure

Name: PROTAC FKBP Degrader-3
Chemical Name: PROTAC FKBP Degrader-3
CAS Number: 2079056-43-0
Molecular Formula: C₆₈H₉₀N₆O₁₇S
Molecular Weight: 1295.54
Catalog: Signaling Pathways PROTAC PROTAC
Create Date: 2020-06-01 18:40:19
Modify Date: 2024-01-10 08:42:40
PROTAC FKBP Degrader-3 is a PROTAC that comprises a FKBP ligand binding group, a linker and an VHL binding group. PROTAC FKBP Degrader-3 is a potent FKBP degrader[1].

Name	PROTAC FKBP Degrader-3

Description	PROTAC FKBP Degrader-3 is a PROTAC that comprises a FKBP ligand binding group, a linker and an VHL binding group. PROTAC FKBP Degrader-3 is a potent FKBP degrader[1].
Related Catalog	Research Areas >> Cancer Signaling Pathways >> PROTAC >> PROTAC
Target	VHL FKBP
In Vitro	PROTAC treatment time courses demonstrated a notable increase in polyubiquitination of EGFP-FKBP in response to treatment with 250 nM of PROTAC FKBP Degrader-3 (compound 10) for VHL within the first hour. Upon recruiting endogenous VHL via PROTAC FKBP Degrader-3 (compound 10), only one EGFP background lysine (Lys158) is found to be ubiquitylated[1].
References	[1]. Ottis P, et al. Assessing Different E3 Ligases for Small Molecule Induced Protein Ubiquitination and Degradation. ACS Chem Biol. 2017 Oct 20;12(10):2570-2578.