(4,5,5,5,5',5',5'-2H7)Leucine

Modify Date: 2024-01-09 17:08:08

(4,5,5,5,5',5',5'-2H7)Leucine Structure
(4,5,5,5,5',5',5'-2H7)Leucine structure
Common Name (4,5,5,5,5',5',5'-2H7)Leucine
CAS Number 259225-40-6 Molecular Weight 138.22
Density 1.0±0.1 g/cm3 Boiling Point 225.8±23.0 °C at 760 mmHg
Molecular Formula C6H6D7NO2 Melting Point 293-296ºC (subl.)(lit.)
MSDS N/A Flash Point 90.3±22.6 °C

 Use of (4,5,5,5,5',5',5'-2H7)Leucine


(±)-Leucine-d7 is the deuterium labeled (±)-Leucine. (±)-Leucine (DL-Leucine), an isomer of Leucine, chemosterilant and dietary additive. (±)-Leucine inhibits growth of Escherichia coli HfrH by 92.08%[1].

 Names

Name dl-leucine-4,5,5,5,6,6,6-d7
Synonym More Synonyms

 (4,5,5,5,5',5',5'-2H7)Leucine Biological Activity

Description (±)-Leucine-d7 is the deuterium labeled (±)-Leucine. (±)-Leucine (DL-Leucine), an isomer of Leucine, chemosterilant and dietary additive. (±)-Leucine inhibits growth of Escherichia coli HfrH by 92.08%[1].
Related Catalog
In Vitro Stable heavy isotopes of hydrogen, carbon, and other elements have been incorporated into drug molecules, largely as tracers for quantitation during the drug development process. Deuteration has gained attention because of its potential to affect the pharmacokinetic and metabolic profiles of drugs[1].
References

[1]. Russak EM, et al. Impact of Deuterium Substitution on the Pharmacokinetics of Pharmaceuticals. Ann Pharmacother. 2019;53(2):211-216.

[2]. Hendricks DE, et, al. Attractiveness of tobacco budworm females altered by oral chemosterilants and dietary additives. Journal of Chemical Ecology. 1977 Mar; 127-131.

 Chemical & Physical Properties

Density 1.0±0.1 g/cm3
Boiling Point 225.8±23.0 °C at 760 mmHg
Melting Point 293-296ºC (subl.)(lit.)
Molecular Formula C6H6D7NO2
Molecular Weight 138.22
Flash Point 90.3±22.6 °C
Exact Mass 138.138565
PSA 63.32000
LogP 0.73
Vapour Pressure 0.0±0.9 mmHg at 25°C
Index of Refraction 1.463
Storage condition -20C

 Synonyms

Leucine-4,5,5,5,5',5',5'-d
(4,5,5,5,5',5',5'-H)Leucine