JZP 361

Modify Date: 2024-01-08 09:32:38

JZP 361 structure	Common Name	JZP 361
	CAS Number	1680193-80-9	Molecular Weight	405.880
	Density	1.4±0.1 g/cm3	Boiling Point	611.7±65.0 °C at 760 mmHg
	Molecular Formula	C₂₂H₂₀ClN₅O	Melting Point	N/A
	MSDS	N/A	Flash Point	323.8±34.3 °C

Use of JZP 361

JZP-361 is a potent and reversible inhibitor of human recombinant MAGL (hMAGL, IC50=46 nM), and has almost 150-fold higher selectivity over human recombinant fatty acid amide hydrolase (hFAAH, IC50=7.24 μM) and 35-fold higher selectivity over human α/β-hydrolase-6 (hABHD6, IC50=1.79 μM). JZP-361 represents a dual-acting pharmacological tool possessing both MAGL inhibitory and antihistaminergic activities[1].

Name	[4-(8-Chloro-5,6-dihydro-11H-benzo[5,6]cyclohepta[1,2-b]pyridin-11-ylidene)-1-piperidinyl](1H-1,2,4-triazol-1-yl)methanone
Synonym	More Synonyms

Description	JZP-361 is a potent and reversible inhibitor of human recombinant MAGL (hMAGL, IC50=46 nM), and has almost 150-fold higher selectivity over human recombinant fatty acid amide hydrolase (hFAAH, IC50=7.24 μM) and 35-fold higher selectivity over human α/β-hydrolase-6 (hABHD6, IC50=1.79 μM). JZP-361 represents a dual-acting pharmacological tool possessing both MAGL inhibitory and antihistaminergic activities[1].
Related Catalog	Signaling Pathways >> Immunology/Inflammation >> Histamine Receptor Signaling Pathways >> Metabolic Enzyme/Protease >> MAGL Research Areas >> Inflammation/Immunology Signaling Pathways >> GPCR/G Protein >> Histamine Receptor
Target	H1 Receptor:6.81 (pA2)
References	[1]. Jayendra Z Patel, et al. Loratadine analogues as MAGL inhibitors. Bioorg Med Chem Lett. 2015 Apr 1;25(7):1436-42.

Density	1.4±0.1 g/cm3
Boiling Point	611.7±65.0 °C at 760 mmHg
Molecular Formula	C₂₂H₂₀ClN₅O
Molecular Weight	405.880
Flash Point	323.8±34.3 °C
Exact Mass	405.135651
LogP	3.88
Vapour Pressure	0.0±1.8 mmHg at 25°C
Index of Refraction	1.725

[4-(8-Chloro-5,6-dihydro-11H-benzo[5,6]cyclohepta[1,2-b]pyridin-11-ylidene)-1-piperidinyl](1H-1,2,4-triazol-1-yl)methanone

Methanone, [4-(8-chloro-5,6-dihydro-11H-benzo[5,6]cyclohepta[1,2-b]pyridin-11-ylidene)-1-piperidinyl]-1H-1,2,4-triazol-1-yl-

JZP 361

Use of JZP 361

Names

JZP 361 Biological Activity

Chemical & Physical Properties

Synonyms