897016-26-1

897016-26-1 structure

Name: KX2-361
Chemical Name: RVW387BA9U
CAS Number: 897016-26-1
Molecular Formula: C₂₄H₂₄FN₃O₂
Molecular Weight: 405.46
Catalog: Signaling Pathways Apoptosis Apoptosis
Create Date: 2018-07-20 05:12:53
Modify Date: 2024-02-02 01:07:00
KX2-361 (KX-02) is a Src-kinase and tubulin polymerization inhibitor. KX2-361 shows good oral bioavailability and readily crosses the BBB in mice. KX2-361 shows anti-tumor activity and induces apoptosis of Glioblastoma (GBM) cell[1].

Name	RVW387BA9U
Synonyms	N-(3-Fluorobenzyl)-2-{5-[4-(4-morpholinyl)phenyl]-2-pyridinyl}acetamide RVW387BA9U 2-Pyridineacetamide, N-[(3-fluorophenyl)methyl]-5-[4-(4-morpholinyl)phenyl]-

Description	KX2-361 (KX-02) is a Src-kinase and tubulin polymerization inhibitor. KX2-361 shows good oral bioavailability and readily crosses the BBB in mice. KX2-361 shows anti-tumor activity and induces apoptosis of Glioblastoma (GBM) cell[1].
Related Catalog	Signaling Pathways >> Apoptosis >> Apoptosis Research Areas >> Cancer Signaling Pathways >> Cell Cycle/DNA Damage >> Microtubule/Tubulin Signaling Pathways >> Protein Tyrosine Kinase/RTK >> Src Signaling Pathways >> Cytoskeleton >> Microtubule/Tubulin
References	[1]. Ciesielski MJ, et al. KX2-361: a novel orally bioavailable small molecule dual Src/tubulin inhibitor that provides long term survival in a murine model of glioblastoma. J Neurooncol. 2018 Dec;140(3):519-527.