1672691-74-5

1672691-74-5 structure

Name: JZP 430
Chemical Name: JZP-430
CAS Number: 1672691-74-5
Molecular Formula: C₁₆H₂₆N₄O₃S
Molecular Weight: 354.47
Catalog: Signaling Pathways Metabolic Enzyme/Protease MAGL
Create Date: 2019-06-30 20:43:15
Modify Date: 2025-08-27 17:25:46
JZP-430 is a potent, highly selective, irreversible inhibitor of α/β-hydrolase domain 6 (ABHD6) with an IC50 of 44 nM, exhibits ~230-fold selectivity over fatty acid amide hydrolase (FAAH) and lysosomal acid lipase (LAL)[1].

Name	JZP-430

Description	JZP-430 is a potent, highly selective, irreversible inhibitor of α/β-hydrolase domain 6 (ABHD6) with an IC50 of 44 nM, exhibits ~230-fold selectivity over fatty acid amide hydrolase (FAAH) and lysosomal acid lipase (LAL)[1].
Related Catalog	Signaling Pathways >> Metabolic Enzyme/Protease >> MAGL Research Areas >> Metabolic Disease
Target	IC50: 44 nM (ABHD6, human)[1]
References	[1]. Patel JZ, et al. Optimization of 1,2,5-thiadiazole carbamates as potent and selective ABHD6 inhibitors. ChemMedChem. 2015 Feb;10(2):253-65.

Molecular Formula	C₁₆H₂₆N₄O₃S
Molecular Weight	354.47

Hazard Codes	Xi