1672691-50-7

1672691-50-7 structure

Name: JZP-MA-11
Chemical Name: JZP-MA-11
CAS Number: 1672691-50-7
Molecular Formula: C₁₅H₁₇FN₄O₂S
Molecular Weight: 336.38
Catalog: Signaling Pathways Metabolic Enzyme/Protease MAGL
Create Date: 2023-02-05 15:49:22
Modify Date: 2025-09-12 17:45:33
JZP-MA-11 is a positron emission tomography (PET) ligand targeting the endocannabinoid α/β-hydrolase domain 6 (ABHD6) enzyme. JZP-MA-11 selectively inhibits ABHD6 with an IC50 value of 126 nM. JZP-MA-11 can cross the blood-brain barrier (BBB). [18F]JZP-MA-11 has the potential for preclinical evaluation targeting the brain ABHD6 in mice and nonhuman primate (NHP)[1].

Name	JZP-MA-11

Description	JZP-MA-11 is a positron emission tomography (PET) ligand targeting the endocannabinoid α/β-hydrolase domain 6 (ABHD6) enzyme. JZP-MA-11 selectively inhibits ABHD6 with an IC50 value of 126 nM. JZP-MA-11 can cross the blood-brain barrier (BBB). [18F]JZP-MA-11 has the potential for preclinical evaluation targeting the brain ABHD6 in mice and nonhuman primate (NHP)[1].
Related Catalog	Signaling Pathways >> Metabolic Enzyme/Protease >> MAGL Research Areas >> Neurological Disease
In Vitro	JZP-MA-11 (10 μM) 对表达 CB1 或 CB2 的 HEK293 细胞中毛喉素 (HY-15371) 刺激的 cAMP 没有影响[1]。
In Vivo	JZP-MA-11 (1.5 mg/kg; 静脉给药; 示踪剂注射前 20 分钟) 导致大脑、肝脏、心脏和肾脏等富含 ABHD6 的器官的放射性摄取减少[1]。 Animal Model: C57BL6 mice (female, 10-12-week-old)[1] Dosage: 1.5 mg/kg Administration: IV; 20 min before tracer injection Result: Resulted in a decrease in radioactivity uptake in ABHD6-rich organs such as, brain, liver, heart, and kidneys.
References	[1]. Karine Mardon, et al.Utilizing PET and MALDI Imaging for Discovery of a Targeted Probe for Brain Endocannabinoid α/ β-Hydrolase Domain 6 (ABHD6). J Med Chem. 2022 Dec 14.

Molecular Formula	C₁₅H₁₇FN₄O₂S
Molecular Weight	336.38