2055741-39-2
2055741-39-2 structure
- Name: IV-361
- Chemical Name: IV-361
- CAS Number: 2055741-39-2
- Molecular Formula: C23H32FN5O2Si
- Molecular Weight: 457.62
- Catalog: Signaling Pathways Cell Cycle/DNA Damage CDK
- Create Date: 2021-09-06 09:34:08
- Modify Date: 2023-02-01 15:29:07
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IV-361 is an orally active and selective CDK7 inhibitor (Ki≤50 nM). IV-361 has anti-cancer activity (US20190256531A1)[1].
| Name | IV-361 |
|---|
| Description | IV-361 is an orally active and selective CDK7 inhibitor (Ki≤50 nM). IV-361 has anti-cancer activity (US20190256531A1)[1]. |
|---|---|
| Related Catalog | |
| Target |
CDK7:≤50 nM (Ki) CDK2:≥1000 nM (Ki) |
| In Vitro | IV-361 has less inhibition on CDK2 (Ki≥1000 nM) or PLK1 (Ki≥5000 nM)[1]. IV-361 exhibits excellent IL-2 and IL-17 production inhibitory activity (all IC50≤100 nM) in periphery blood mononuclear cell (PBMC)[1]. IV-361 exhibits excellent HCT-116 cell growth inhibitory activity (GI50≤100 nM)[1]. |
| In Vivo | IV-361 (25 mg/kg/day; orally) exhibits 46% or more rate of suppression of tumor volume in female BALB nude mice with HCT-116[1]. |
| References |
[1]. Noriaki Iwase, et al. Substituted dihydropyrrolopyrazole derivative. US20190256531A1. |
| Molecular Formula | C23H32FN5O2Si |
|---|---|
| Molecular Weight | 457.62 |