5'-ODMT cEt m5U Phosphoramidite (Amidite)

Modify Date: 2024-01-06 22:35:23

5'-ODMT cEt m5U Phosphoramidite (Amidite) structure	Common Name	5'-ODMT cEt m5U Phosphoramidite (Amidite)
	CAS Number	1197033-22-9	Molecular Weight	786.85000
	Density	N/A	Boiling Point	N/A
	Molecular Formula	C₄₂H₅₁N₄O₉P	Melting Point	N/A
	MSDS	N/A	Flash Point	N/A

Use of 5'-ODMT cEt m5U Phosphoramidite (Amidite)

5'-ODMT cEt m5U Phosphoramidite Amidite is a locked nucleic acid (LNA) analog. 5'-ODMT cEt m5U Phosphoramidite Amidite shows excellent safety and antisense activity[1][2].

Name	3-[[(1R,3S,4S,6R,7S)-4-[[bis(4-methoxyphenyl)-phenylmethoxy]methyl]-3-methyl-6-(5-methyl-2,4-dioxopyrimidin-1-yl)-2,5-dioxabicyclo[2.2.1]heptan-7-yl]oxy-[di(propan-2-yl)amino]phosphanyl]oxypropanenitrile

Description	5'-ODMT cEt m5U Phosphoramidite Amidite is a locked nucleic acid (LNA) analog. 5'-ODMT cEt m5U Phosphoramidite Amidite shows excellent safety and antisense activity[1][2].
Related Catalog	Signaling Pathways >> Cell Cycle/DNA Damage >> Nucleoside Antimetabolite/Analog Research Areas >> Others
References	[1]. Fiona J. Laraman, et al. Investigating the Activation Kinetics of Phosphoramidites for Oligonucleotide Synthesis. Org. Process Res. Dev. 2022, 26, 3, 764-772. [2]. Vasquez G, et al. Site-specific incorporation of 5'-methyl DNA enhances the therapeutic profile of gapmer ASOs. Nucleic Acids Res. 2021 Feb 26;49(4):1828-1839.

Description

5'-ODMT cEt m5U Phosphoramidite Amidite is a locked nucleic acid (LNA) analog. 5'-ODMT cEt m5U Phosphoramidite Amidite shows excellent safety and antisense activity[1][2].

Related Catalog

Signaling Pathways >> Cell Cycle/DNA Damage >> Nucleoside Antimetabolite/Analog

Research Areas >> Others

References

[1]. Fiona J. Laraman, et al. Investigating the Activation Kinetics of Phosphoramidites for Oligonucleotide Synthesis. Org. Process Res. Dev. 2022, 26, 3, 764-772.

[2]. Vasquez G, et al. Site-specific incorporation of 5'-methyl DNA enhances the therapeutic profile of gapmer ASOs. Nucleic Acids Res. 2021 Feb 26;49(4):1828-1839.

Molecular Formula	C₄₂H₅₁N₄O₉P
Molecular Weight	786.85000
Exact Mass	786.33900
PSA	160.35000
LogP	6.99928

1-[(1R,3S,4R,6R...

CAS#:1197033-21-8

2-Cyanoethyltet...

CAS#:102691-36-1

~95%

5'-ODMT cEt m5U...

CAS#:1197033-22-9

Literature: Seth, Punit P.; Vasquez, Guillermo; Allerson, Charles A.; Berdeja, Andres; Gaus, Hans; Kinberger, Garth A.; Prakash, Thazha P.; Migawa, Michael T.; Bhat, Balkrishen; Swayze, Eric E. Journal of Organic Chemistry, 2010 , vol. 75, # 5 p. 1569 - 1581

Precursor 2
CAS#:1197033-21-8 1-[(1R,3S,4R,6R... CAS#:102691-36-1 2-Cyanoethyltet...
DownStream 0

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5'-ODMT cEt m5U Phosphoramidite (Amidite)

Use of 5'-ODMT cEt m5U Phosphoramidite (Amidite)

Names

Biological Activity

Chemical & Physical Properties

Synthetic Route

Precursor & DownStream

The content on this webpage is sourced from various professional data sources. If you have any questions or concerns regarding the content, please feel free to contact service1@chemsrc.com.