1197033-22-9

1197033-22-9 structure

Name: 5'-ODMT cEt m5U Phosphoramidite (Amidite)
Chemical Name: 3-[[(1R,3S,4S,6R,7S)-4-[[bis(4-methoxyphenyl)-phenylmethoxy]methyl]-3-methyl-6-(5-methyl-2,4-dioxopyrimidin-1-yl)-2,5-dioxabicyclo[2.2.1]heptan-7-yl]oxy-[di(propan-2-yl)amino]phosphanyl]oxypropanenitrile
CAS Number: 1197033-22-9
Molecular Formula: C₄₂H₅₁N₄O₉P
Molecular Weight: 786.85000
Catalog: Signaling Pathways Cell Cycle/DNA Damage Nucleoside Antimetabolite/Analog
Create Date: 2016-09-07 22:42:20
Modify Date: 2024-01-06 22:35:23
5'-ODMT cEt m5U Phosphoramidite Amidite is a locked nucleic acid (LNA) analog. 5'-ODMT cEt m5U Phosphoramidite Amidite shows excellent safety and antisense activity[1][2].

Name	3-[[(1R,3S,4S,6R,7S)-4-[[bis(4-methoxyphenyl)-phenylmethoxy]methyl]-3-methyl-6-(5-methyl-2,4-dioxopyrimidin-1-yl)-2,5-dioxabicyclo[2.2.1]heptan-7-yl]oxy-[di(propan-2-yl)amino]phosphanyl]oxypropanenitrile

Description	5'-ODMT cEt m5U Phosphoramidite Amidite is a locked nucleic acid (LNA) analog. 5'-ODMT cEt m5U Phosphoramidite Amidite shows excellent safety and antisense activity[1][2].
Related Catalog	Signaling Pathways >> Cell Cycle/DNA Damage >> Nucleoside Antimetabolite/Analog Research Areas >> Others
References	[1]. Fiona J. Laraman, et al. Investigating the Activation Kinetics of Phosphoramidites for Oligonucleotide Synthesis. Org. Process Res. Dev. 2022, 26, 3, 764-772. [2]. Vasquez G, et al. Site-specific incorporation of 5'-methyl DNA enhances the therapeutic profile of gapmer ASOs. Nucleic Acids Res. 2021 Feb 26;49(4):1828-1839.

1197033-21-8

102691-36-1

~95%

1197033-22-9

Precursor 2
1197033-21-8 102691-36-1
DownStream 0