We have recently shown that combining the structural elements of 2′ O-methoxyethyl (MOE) and locked nucleic acid (LNA) nucleosides yielded a series of nucleoside modifications (cMOE, 2′, 4′-constrained MOE; cEt, 2′, 4′-constrained ethyl) that display improved potency over MOE and an improved therapeutic index relative to that of LNA antisense oligonucleotides. In this report we present details regarding the synthesis of the ...
![N-[9-[(1R,3S,4R,6R,7S)-7-hydroxy-4-(hydroxymethyl)-3-methyl-2,5-dioxabicyclo[2.2.1]heptan-6-yl]purin-6-yl]benzamide Structure](https://image.chemsrc.com/caspic/250/1197033-12-7.png)
![N-(9-((1R,3R,4R,6S,7S)-1-((Bis(4-methoxyphenyl)(phenyl)methoxy)methyl)-7-hydroxy-6-methyl-2,5-dioxabicyclo[2.2.1]heptan-3-YL)-9H-purin-6-YL)benzamide Structure](https://image.chemsrc.com/caspic/012/1197033-18-3.png)
![1-[(1R,3S,4R,6R,7S)-4-[[bis(4-methoxyphenyl)-phenylmethoxy]methyl]-7-hydroxy-3-methyl-2,5-dioxabicyclo[2.2.1]heptan-6-yl]-5-methylpyrimidine-2,4-dione Structure](https://image.chemsrc.com/caspic/081/1197033-21-8.png)
