Clofarabine
Clofarabine structure
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Common Name | Clofarabine | ||
|---|---|---|---|---|
| CAS Number | 123318-82-1 | Molecular Weight | 303.677 | |
| Density | 2.1±0.1 g/cm3 | Boiling Point | 599.5±60.0 °C at 760 mmHg | |
| Molecular Formula | C10H11ClFN5O3 | Melting Point | 228-231 °C | |
| MSDS | Chinese USA | Flash Point | 316.4±32.9 °C | |
| Symbol |
GHS06 |
Signal Word | Danger | |
Use of ClofarabineClofarabine(Clolar; Clofarex) inhibits the enzymatic activities of ribonucleotide reductase (IC50 = 65 nM) and DNA polymerase.IC50 Value: 65 nMTarget: in vitro: Clofarabine is a second generation purine nucleoside analog with antineoplastic activity. It is phosphorylated intracellularly, which inhibits the enzymatic activities of ribonucleotide reductase (IC50 = 65 nM) and DNA polymerase, resulting in inhibition of DNA repair and synthesis of DNA and RNA. This nucleoside analog also disrupts mitochondrial function and membrane integrity, resulting in the release of pre-apoptotic factors, including cytochrome C and apoptotic-inducing factor, which activate apoptosis.in vivo: Clofarabine is used for treating relapsed or refractory acute lymphoblastic leukaemia (ALL) in children, after at least two other types of treatment have failed. |
This table lists Chinese names, IUPAC names and various aliases of this chemical substance.
| Name | clofarabine |
|---|---|
| Synonym | More Synonyms |
This table contains bioactivity, target information and biological‑assay experimental data of this compound.
| Description | Clofarabine(Clolar; Clofarex) inhibits the enzymatic activities of ribonucleotide reductase (IC50 = 65 nM) and DNA polymerase.IC50 Value: 65 nMTarget: in vitro: Clofarabine is a second generation purine nucleoside analog with antineoplastic activity. It is phosphorylated intracellularly, which inhibits the enzymatic activities of ribonucleotide reductase (IC50 = 65 nM) and DNA polymerase, resulting in inhibition of DNA repair and synthesis of DNA and RNA. This nucleoside analog also disrupts mitochondrial function and membrane integrity, resulting in the release of pre-apoptotic factors, including cytochrome C and apoptotic-inducing factor, which activate apoptosis.in vivo: Clofarabine is used for treating relapsed or refractory acute lymphoblastic leukaemia (ALL) in children, after at least two other types of treatment have failed. |
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| Related Catalog | |
| References |
This table shows physicochemical parameters including melting point, boiling point, density, solubility and optical rotation. Missing data is marked as N/A.
| Density | 2.1±0.1 g/cm3 |
|---|---|
| Boiling Point | 599.5±60.0 °C at 760 mmHg |
| Melting Point | 228-231 °C |
| Molecular Formula | C10H11ClFN5O3 |
| Molecular Weight | 303.677 |
| Flash Point | 316.4±32.9 °C |
| Exact Mass | 303.053436 |
| PSA | 119.31000 |
| LogP | 0.24 |
| Vapour Pressure | 0.0±1.8 mmHg at 25°C |
| Index of Refraction | 1.844 |
| InChIKey | WDDPHFBMKLOVOX-AYQXTPAHSA-N |
| SMILES | Nc1nc(Cl)nc2c1ncn2C1OC(CO)C(O)C1F |
This table provides MSDS information including hazard classification, first‑aid, fire‑fighting, spill handling, operation and storage instructions.
This table summarizes toxicological test data, acute & chronic toxicity and ecological hazard parameters for this chemical.
CHEMICAL IDENTIFICATION
HEALTH HAZARD DATAACUTE TOXICITY DATAMUTATION DATA
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This table covers safety warnings, protective measures, incompatible substances and disposal guidelines for this compound.
| Symbol |
GHS06 |
|---|---|
| Signal Word | Danger |
| Hazard Statements | H300 |
| Precautionary Statements | P264-P301 + P310 |
| Personal Protective Equipment | Eyeshields;Faceshields;Gloves;type P2 (EN 143) respirator cartridges |
| Hazard Codes | Xi,C |
| Risk Phrases | R36/37/38:Irritating to eyes, respiratory system and skin . R20/21/22:Harmful by inhalation, in contact with skin and if swallowed . |
| Safety Phrases | S26-S36-S45-S36/37/39 |
| RIDADR | UN 2735 8/PG 3 |
| WGK Germany | 3 |
| RTECS | DP5550000 |
| Packaging Group | III |
| Hazard Class | 8 |
This table presents publicly reported synthetic routes, reaction conditions, reactants and product information of the compound.
This table lists upstream starting materials and downstream derivative products related to this chemical.
| Precursor 9 | |
|---|---|
| DownStream 2 | |
CAS#:355138-50-0
CAS#:97614-43-2
CAS#:97614-44-3
CAS#:6974-32-9
CAS#:1839-18-5
CAS#:1055168-98-3
CAS#:1353040-42-2
CAS#:103884-99-7
CAS#:75788-35-1
CAS#:850883-62-4This table lists relevant public references with title, journal and publication metadata for this compound.
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The potential of clofarabine in MLL-rearranged infant acute lymphoblastic leukaemia.
Eur. J. Cancer 51 , 2008-21, (2015) MLL-rearranged acute lymphoblastic leukaemia (ALL) in infants is the most difficult-to-treat type of childhood ALL, displaying a chemotherapy-resistant phenotype, and unique histone modifications, gen... |
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Preclinical examination of clofarabine in pediatric ependymoma: intratumoral concentrations insufficient to warrant further study.
Cancer Chemother. Pharmacol. 75 , 897-906, (2015) Clofarabine, a deoxyadenosine analog, was an active anticancer drug in our in vitro high-throughput screening against mouse ependymoma neurospheres. To characterize the clofarabine disposition in mice... |
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Knockdown of Bcl-xL enhances growth-inhibiting and apoptosis-inducing effects of resveratrol and clofarabine in malignant mesothelioma H-2452 cells.
J. Korean Med. Sci. 29(11) , 1464-72, (2014) Mcl-1 and Bcl-xL, key anti-apoptotic proteins of the Bcl-2 family, have attracted attention as important molecules in the cell survival and drug resistance. In this study, we investigated whether inhi... |
This table contains target information, in‑vitro & in‑vivo assay data for this compound.
This table collects all English aliases, systematic names and CAS‑related synonyms of the compound.
| Clofarex |
| (2R,3R,4S,5R)-5-(6-amino-2-chloropurin-9-yl)-4-fluoro-2-(hydroxymethyl)oxolan-3-ol |
| (2R,3R,4S,5R)-5-(6-amino-2-chloro-9H-purin-9-yl)-4-fluoro-2-(hydroxyméthyl)tétrahydrofuran-3-ol |
| 2-Chloro-9-(2-deoxy-2-fluoro-β-D-arabinofuranosyl)adenine |
| (2R,3R,4S,5R)-5-(6-Amino-2-chlor-9H-purin-9-yl)-4-fluor-2-(hydroxymethyl)tetrahydrofuran-3-ol |
| (2R,3R,4S,5R)-5-(6-amino-2-chloro-9H-purin-9-yl)-4-fluoro-2-(hydroxymethyl)tetrahydrofuran-3-ol |
| 2-chloro-2'-arabino-fluoro-2'-deoxyadenosine |
| Cl-F-Ara-A |
| Clofarabine |
| Clofarabine [USAN] |
| Clolar |
| 2-Chloro-9-(2-deoxy-2-fluoro-β-D-arabinofuranosyl)-9H-purin-6-amine |
| MFCD00871077 |
This section contains frequently‑asked‑questions about this compound, including basic parameters, properties, storage conditions and corresponding answers.
| Q: What is the CAS number of clofarabine? |
| A: CAS number of clofarabine is 123318-82-1. |
| Q: What is the InChIKey of clofarabine? |
| A: InChIKey of clofarabine is WDDPHFBMKLOVOX-AYQXTPAHSA-N. |
| Q: What is the safety information for clofarabine? |
| A: Safety information for clofarabine: S26-S36-S45-S36/37/39. |
| Q: What is the LogP of clofarabine? |
| A: LogP of clofarabine is 0.24. |
| Q: What is the English name of clofarabine? |
| A: The English name of clofarabine is clofarabine. |
| Q: What is the SMILES notation of clofarabine? |
| A: SMILES notation of clofarabine is Nc1nc(Cl)nc2c1ncn2C1OC(CO)C(O)C1F. |
| Q: What are the downstream products of clofarabine? |
| A: Related downstream products(CAS) of clofarabine: 1839-18-5;850883-62-4. |
| Q: What is the molecular formula of clofarabine? |
| A: Molecular formula of clofarabine is C10H11ClFN5O3. |
| Q: What is the melting point of clofarabine? |
| A: Melting point of clofarabine is 228-231 °C. |
| Q: What is the boiling point of clofarabine? |
| A: Boiling point of clofarabine is 599.5±60.0 °C at 760 mmHg. |
This table lists manufacturers and suppliers of this compound, including vendor names and product supply reference information.
| Shanghai Nianxing Industrial Co., Ltd |
| Dayang Chem (Hangzhou) Co., Ltd. |
| Henan Tianfu Chemical Co., Ltd. |