4-AMINO-1,8-NAPHTHALIMIDE

Modify Date: 2026-07-01 21:50:59

4-AMINO-1,8-NAPHTHALIMIDE structure	Common Name	4-AMINO-1,8-NAPHTHALIMIDE
	CAS Number	1742-95-6	Molecular Weight	212.20
	Density	1.105 g/mL at 25ºC(lit.)	Boiling Point	544.1ºC at 760 mmHg
	Molecular Formula	C₁₂H₈N₂O₂	Melting Point	360ºC
	MSDS	Chinese USA	Flash Point	282.8ºC
	Symbol	GHS07	Signal Word	Warning

Use of 4-AMINO-1,8-NAPHTHALIMIDE

4-Aminonaphthalimide is a potent PARP inhibitor and potentiates the cytotoxicity of γ-radiation in cancer cells[1].

This table lists Chinese names, IUPAC names and various aliases of this chemical substance.

Name	4-amino-1,8-naphthalimide
Synonym	More Synonyms

This table contains bioactivity, target information and biological‑assay experimental data of this compound.

Description	4-Aminonaphthalimide is a potent PARP inhibitor and potentiates the cytotoxicity of γ-radiation in cancer cells[1].
Related Catalog	Research Areas >> Cancer Signaling Pathways >> Epigenetics >> PARP Signaling Pathways >> Cell Cycle/DNA Damage >> PARP
References	[1]. Schlicker A, et al. 4-Amino-1,8-naphthalimide: a novel inhibitor of poly(ADP-ribose) polymerase and radiation sensitizer. Int J Radiat Biol. 1999 Jan;75(1):91-100.

This table shows physicochemical parameters including melting point, boiling point, density, solubility and optical rotation. Missing data is marked as N/A.

Density	1.105 g/mL at 25ºC(lit.)
Boiling Point	544.1ºC at 760 mmHg
Melting Point	360ºC
Molecular Formula	C₁₂H₈N₂O₂
Molecular Weight	212.20
Flash Point	282.8ºC
Exact Mass	212.05900
PSA	75.95000
LogP	1.64270
Vapour Pressure	6.75E-12mmHg at 25°C
Index of Refraction	1.764
InChIKey	SSMIFVHARFVINF-UHFFFAOYSA-N
SMILES	Nc1ccc2c3c(cccc13)C(=O)NC2=O

This table provides MSDS information including hazard classification, first‑aid, fire‑fighting, spill handling, operation and storage instructions.

4-AMINO-1,8-NAPHTHALIMIDE MSDS(Chinese)

This table summarizes toxicological test data, acute & chronic toxicity and ecological hazard parameters for this chemical.

CHEMICAL IDENTIFICATION

RTECS NUMBER :: DE4081000

CHEMICAL NAME :: 1H-Benz(de)isoquinoline-1,3(2H)-dione, 6-amino-

CAS REGISTRY NUMBER :: 1742-95-6

BEILSTEIN REFERENCE NO. :: 0177185

LAST UPDATED :: 199701

DATA ITEMS CITED :: 2

MOLECULAR FORMULA :: C12-H8-N2-O2

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

TYPE OF TEST :: LD - Lethal dose

ROUTE OF EXPOSURE :: Oral

SPECIES OBSERVED :: Rodent - rat

DOSE/DURATION :: >10 gm/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

REFERENCE :: GISAAA Gigiena i Sanitariya. For English translation, see HYSAAV. (V/O Mezhdunarodnaya Kniga, 113095 Moscow, USSR) V.1- 1936- Volume(issue)/page/year: 42(1),111,1977

This table covers safety warnings, protective measures, incompatible substances and disposal guidelines for this compound.

Symbol	GHS07
Signal Word	Warning
Hazard Statements	H315-H319-H335
Precautionary Statements	P261-P305 + P351 + P338
Personal Protective Equipment	dust mask type N95 (US);Eyeshields;Gloves
Hazard Codes	Xi: Irritant;
Risk Phrases	R36/37/38
Safety Phrases	26-37/39
RIDADR	NONH for all modes of transport
RTECS	DE4081000

This table presents publicly reported synthetic routes, reaction conditions, reactants and product information of the compound.

6-Nitro-1H,3H-b...

CAS#:6642-29-1

~51%

4-AMINO-1,8-NAP...

CAS#:1742-95-6

Learn More

Literature: Alexiou, Michael; Tyman, John; Wilson, Ian Tetrahedron Letters, 1981 , vol. 22, # 24 p. 2303 - 2306

N/A

CAS#:26848-63-5

4-AMINO-1,8-NAP...

CAS#:1742-95-6

Learn More

Literature: DE602944 , ; Fortschr. Teerfarbenfabr. Verw. Industriezweige, vol. 21, p. 370 US2006017 , ;

This table lists upstream starting materials and downstream derivative products related to this chemical.

Precursor 1
CAS#:6642-29-1 6-Nitro-1H,3H-b...
DownStream 0

This table lists relevant public references with title, journal and publication metadata for this compound.

A new polymerizable fluorescent PET chemosensor of fluoride (F-) based on naphthalimide-thiourea dye.

Spectrochim. Acta. A. Mol. Biomol. Spectrosc. 90 , 85-92, (2012)

A novel N-allyl-4-amino-substituted 1,8-naphthalimide dye, containing thiourea functional group with intense yellow-green fluorescence was successfully synthesized. Copolymerization was done with styr...

Preventing oxidation of cellular XRCC1 affects PARP-mediated DNA damage responses.

DNA Repair (Amst.) 12(9) , 774-85, (2013)

Poly(ADP-ribose) polymerase-1 (PARP-1) binds intermediates of base excision repair (BER) and becomes activated for poly(ADP-ribose) (PAR) synthesis. PAR mediates recruitment and functions of the key B...

[Effect of PARP-1 inhibitor 4-amino-1 ,8-naphthalimide on the on the sensitivity of adriamycin].

Wei Sheng Yan Jiu 41(2) , 173-9, (2012)

To explore the effect of inhibition of poly (ADP-ribose) polymerase-1 (PARP-1) on the sensitivity of cells to adriamycin (ADM).Mouse embryonic fibroblasts (MEFs) were divided into two groups according...

This table contains target information, in‑vitro & in‑vivo assay data for this compound.

Name: DRUGMATRIX: Opiate delta1 (OP1, DOP) radioligand binding (ligand: [3H] Naltrindole)
Source: ChEMBL
Target: Delta-type opioid receptor
External Id: CHEMBL1909180

Name: DRUGMATRIX: Nitric Oxide Synthase, Inducible (iNOS) enzyme inhibition (substrate: L-A...
Source: ChEMBL
Target: Nitric oxide synthase, inducible
External Id: CHEMBL1909179

Name: DRUGMATRIX: Opiate mu (OP3, MOP) radioligand binding (ligand: [3H] Diprenorphine)
Source: ChEMBL
Target: Mu-type opioid receptor
External Id: CHEMBL1909182

Name: Inhibition of neurosphere proliferation of mouse neural precursor cells by MTT assay
Source: ChEMBL
Target: N/A
External Id: CHEMBL1266185

Name: Primary qHTS assay for inhibitors of alpha-synuclein gene (SNCA) expression
Source: NCGC
External Id: SNCA-p-activity-luciferase

Name: DRUGMATRIX: Opiate kappa (OP2, KOP) radioligand binding (ligand: [3H] Diprenorphine)
Source: ChEMBL
Target: Kappa-type opioid receptor
External Id: CHEMBL1909181

Name: DRUGMATRIX: Phosphodiesterase PDE3 enzyme inhibition (substrate: [3H]cAMP + cAMP)
Source: ChEMBL
Target: N/A
External Id: CHEMBL1909184

Name: DRUGMATRIX: Phorbol Ester radioligand binding (ligand: [3H] PDBu)
Source: ChEMBL
Target: N/A
External Id: CHEMBL1909183

Name: DRUGMATRIX: Phosphodiesterase PDE5 enzyme inhibition (substrate: [3H]cGMP + cGMP)
Source: ChEMBL
Target: cGMP-specific 3',5'-cyclic phosphodiesterase
External Id: CHEMBL1909186

Name: DRUGMATRIX: Phosphodiesterase PDE4 enzyme inhibition (substrate: [3H]cAMP + cAMP)
Source: ChEMBL
Target: N/A
External Id: CHEMBL1909185

Total 229, Current Page 1 of 23

This table collects all English aliases, systematic names and CAS‑related synonyms of the compound.

6-aminobenzo[de]isoquinoline-1,3-dione

EINECS 217-092-5

4-Amino-1,8-naphthalimide

6-Amino-1H-benzo[de]isoquinoline-1,3(2H)-dione

MFCD00001892

This section contains frequently‑asked‑questions about this compound, including basic parameters, properties, storage conditions and corresponding answers.

Q: What are the upstream materials of 4-amino-1,8-naphthalimide?

A: Related upstream materials(CAS) of 4-amino-1,8-naphthalimide: 6642-29-1.

Q: What is the SMILES notation of 4-amino-1,8-naphthalimide?

A: SMILES notation of 4-amino-1,8-naphthalimide is Nc1ccc2c3c(cccc13)C(=O)NC2=O.

Q: What is the CAS number of 4-amino-1,8-naphthalimide?

A: CAS number of 4-amino-1,8-naphthalimide is 1742-95-6.

Q: What is the InChIKey of 4-amino-1,8-naphthalimide?

A: InChIKey of 4-amino-1,8-naphthalimide is SSMIFVHARFVINF-UHFFFAOYSA-N.

Q: What English synonyms does 4-amino-1,8-naphthalimide have?

A: English synonyms of 4-amino-1,8-naphthalimide: 6-aminobenzo[de]isoquinoline-1,3-dione, EINECS 217-092-5, 4-Amino-1,8-naphthalimide, 6-Amino-1H-benzo[de]isoquinoline-1,3(2H)-dione, MFCD00001892.

Q: What is the LogP of 4-amino-1,8-naphthalimide?

A: LogP of 4-amino-1,8-naphthalimide is 1.64270.

Q: What are the uses of 4-amino-1,8-naphthalimide?

A: Main uses of 4-amino-1,8-naphthalimide: 4-Aminonaphthalimide is a potent PARP inhibitor and potentiates the cytotoxicity of γ-radiation in cancer cells[1].

Q: What is the safety information for 4-amino-1,8-naphthalimide?

A: Safety information for 4-amino-1,8-naphthalimide: 26-37/39.

Q: What is the polar surface area (PSA) of 4-amino-1,8-naphthalimide?

A: Polar surface area (PSA) of 4-amino-1,8-naphthalimide is 75.95000.

Q: What is the boiling point of 4-amino-1,8-naphthalimide?

A: Boiling point of 4-amino-1,8-naphthalimide is 544.1ºC at 760 mmHg.

This table lists manufacturers and suppliers of this compound, including vendor names and product supply reference information.

Shanghai Nianxing Industrial Co., Ltd

Dayang Chem (Hangzhou) Co., Ltd.

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Shanghai Nianxing Industrial Co., Ltd
China
Product Name: 4-AMINO-1,8-NAPHTHALIMIDE
Price: Check
Purity: 98.0%
Delivery: 10 Day
Contact: Yang
Email: sales@echemcloud.com

Dayang Chem (Hangzhou) Co., Ltd.
China
Product Name: 4-aminonaphthalene-1,8-dicarboximide
Price: $Inquiry/100g $Inquiry/1kg $Inquiry/100kg $Inquiry/1000kg
Purity: 98.0%
Delivery: Inquiry
Contact: Ms Wang
Email: enquiry@dycnchem.com

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