4-AMINO-1,8-NAPHTHALIMIDE
4-AMINO-1,8-NAPHTHALIMIDE structure
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Common Name | 4-AMINO-1,8-NAPHTHALIMIDE | ||
|---|---|---|---|---|
| CAS Number | 1742-95-6 | Molecular Weight | 212.20 | |
| Density | 1.105 g/mL at 25ºC(lit.) | Boiling Point | 544.1ºC at 760 mmHg | |
| Molecular Formula | C12H8N2O2 | Melting Point | 360ºC | |
| MSDS | Chinese USA | Flash Point | 282.8ºC | |
| Symbol |
GHS07 |
Signal Word | Warning | |
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A new polymerizable fluorescent PET chemosensor of fluoride (F-) based on naphthalimide-thiourea dye.
Spectrochim. Acta. A. Mol. Biomol. Spectrosc. 90 , 85-92, (2012) A novel N-allyl-4-amino-substituted 1,8-naphthalimide dye, containing thiourea functional group with intense yellow-green fluorescence was successfully synthesized. Copolymerization was done with styrene. The photophysical characteristics of dye and its copol... |
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Preventing oxidation of cellular XRCC1 affects PARP-mediated DNA damage responses.
DNA Repair (Amst.) 12(9) , 774-85, (2013) Poly(ADP-ribose) polymerase-1 (PARP-1) binds intermediates of base excision repair (BER) and becomes activated for poly(ADP-ribose) (PAR) synthesis. PAR mediates recruitment and functions of the key BER factors XRCC1 and DNA polymerase β (pol β) that in turn ... |
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[Effect of PARP-1 inhibitor 4-amino-1 ,8-naphthalimide on the on the sensitivity of adriamycin].
Wei Sheng Yan Jiu 41(2) , 173-9, (2012) To explore the effect of inhibition of poly (ADP-ribose) polymerase-1 (PARP-1) on the sensitivity of cells to adriamycin (ADM).Mouse embryonic fibroblasts (MEFs) were divided into two groups according to whether they were treated with 4-amino-1,8-naphthalimid... |
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Highly selective ratiometric fluorescent probe for Au3+ and its application to bioimaging.
Biosens. Bioelectron. 49 , 438-41, (2013) The 4-propargylamino-1,8-naphthalimide based fluorescent probe 1 has been explored as a sensor for selective detection of Au(3+). 4-Amino-1,8-naphthalimides, that possess typical intramolecular charge transfer (ICT) electronic characteristics, have been widel... |
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A stronger DNA damage-induced G2 checkpoint due to over-activated CHK1 in the absence of PARP-1.
Cell Cycle 5(20) , 2364-70, (2006) Poly(ADP-ribose) polymerase 1 (PARP-1) is involved in multi-pathways to respond to DNA damage. Lack of or inhibition of PARP-1 activity leads to slow progress of cell cycle and sensitization of cells to different stresses. Recently, it was reported that besid... |
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Induction of apoptosis by the inhibitors of poly(ADP-ribose)polymerase in HeLa cells.
Mol. Cell Biochem. 320(1-2) , 15-23, (2009) To investigate the role of poly(ADP-ribose)polymerase (PARP) in the physiological condition of cell growth, we studied the ability of PARP inhibitors to induce apoptosis. Benzamide (BA) and 4-amino-1,8-naphthalimide (NAP), two well-known inhibitors of PARP, t... |
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Alkylation DNA damage in combination with PARP inhibition results in formation of S-phase-dependent double-strand breaks.
DNA Repair (Amst.) 9(8) , 929-36, (2010) The combination of poly(ADP-ribose)polymerase (PARP) inhibitors and alkylating agents is currently being investigated in cancer therapy clinical trials. However, the DNA lesions producing the synergistic cell killing effect in tumors are not fully understood.... |
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Luminescence targeting and imaging using a nanoscale generation 3 dendrimer in an in vivo colorectal metastatic rat model
Nanomedicine: Nanotechnology, Biology, and Medicine 7(3) , 249-58, (2011) Surgery is currently the best approach for treating either primary or metastatic hepatic malignancies. Because only 20% of hepatic cancers are operable in patients, several types of regional therapy (RT) are emerging as alternate treatment modalities. However... |
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Delayed activation of caspase-independent apoptosis during heart failure in transgenic mice overexpressing caspase inhibitor CrmA.
Am. J. Physiol. Heart Circ. Physiol. 299(5) , H1374-81, (2010) Although caspase activation is generally thought to be necessary to induce apoptosis, recent evidence suggests that apoptosis can be activated in the setting of caspase inhibition. In this study, we tested the hypothesis that caspase-independent apoptotic pat... |
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ATR signaling mediates an S-phase checkpoint after inhibition of poly(ADP-ribose) polymerase activity.
DNA Repair (Amst.) 6(6) , 742-50, (2007) Human fibroblasts, capable of expressing a kinase-dead form of ATR (ATRkd), can be sensitized to the cytotoxic effects of methyl methanesulfonate (MMS) by the PARP inhibitor 4-amino-1,8-naphthalimide (4-AN). The combination of MMS+4-AN results in accumulation... |