(-)-Epicatechin gallate

Modify Date: 2025-08-22 19:37:12

(-)-Epicatechin gallate structure	Common Name	(-)-Epicatechin gallate
	CAS Number	1257-08-5	Molecular Weight	442.372
	Density	1.8±0.1 g/cm3	Boiling Point	861.7±65.0 °C at 760 mmHg
	Molecular Formula	C₂₂H₁₈O₁₀	Melting Point	257-258ºC
	MSDS	Chinese USA	Flash Point	305.0±27.8 °C

Use of (-)-Epicatechin gallate

Epicatechin gallate inhibits cyclooxygenase-1 (COX-1) with an IC50 of 7.5 μM.

Name	(-)-epicatechin-3-O-gallate
Synonym	More Synonyms

Description	Epicatechin gallate inhibits cyclooxygenase-1 (COX-1) with an IC50 of 7.5 μM.
Related Catalog	Natural Products >> Flavonoids Research Areas >> Cancer
Target	COX-1:7.5 μM (IC50)
In Vitro	Epicatechin gallate exhibits >95% inhibitory activity at 70 μg/mL against cyclooxygenase-1 (COX-1) with an IC50 of 7.5 μM[1].
In Vivo	Epicatechin gallate ((-)-Epicatechin-3-O-gallate, ECG), a component of Rhei Rhizoma, is one of the active components of Onpi-to, a herbal medicine composed of five crude drugs (Rhei Rhizome, Glycyrrhizae Radix, Ginseng Radix, Zingiberis Rhizoma and Aconiti Tuber). Following intravenous injection of Epicatechin gallate (1.0 mg/kg) in rats, the plasma concentration vs. time curve is fitted in a three compartment model. Pharmacokinetic parameters for plasma Epicatechin gallate (ECG) are measured. ECG has a t1/2α of 0.038 h, a t1/2βof 0.291 h and a t1/2γ of 4.033 h . The CLtot of ECG is 4.19 L/h • kg. The Vdss is 12.39 L/kg[2].
Animal Admin	Rats[2] Male Sprague-Dawley rats, obtained at 7 weeks of age (210-245 g) are used. Epicatechin gallate (ECG) is suspended in 0.5% w/v sodium carboxymethylcellulose at 12.5, 25.0 and 50.0 mg/10 mL for oral administration to rats at 10 mL/kg. For intravenous injection in rats at 1.0 mg/kg, an ethanolic solution of Epicatechin gallate is diluted with 10% w/v sodium citrate solution to 1.0 mg/mL; the final concentration of ethanol is 1% v/v[2].
References	[1]. Waffo-Téguo P, et al. Potential cancer-chemopreventive activities of wine stilbenoids and flavans extracted from grape (Vitis vinifera) cell cultures. Nutr Cancer. 2001;40(2):173-9. [2]. Takizawa Y, et al. Pharmacokinetics of (-)-epicatechin-3-O-gallate, an active component of Onpi-to, in rats. Biol Pharm Bull. 2003 May;26(5):608-12.

Density	1.8±0.1 g/cm3
Boiling Point	861.7±65.0 °C at 760 mmHg
Melting Point	257-258ºC
Molecular Formula	C₂₂H₁₈O₁₀
Molecular Weight	442.372
Flash Point	305.0±27.8 °C
Exact Mass	442.089996
PSA	177.14000
LogP	2.67
Vapour Pressure	0.0±0.3 mmHg at 25°C
Index of Refraction	1.825
InChIKey	LSHVYAFMTMFKBA-TZIWHRDSSA-N
SMILES	O=C(OC1Cc2c(O)cc(O)cc2OC1c1ccc(O)c(O)c1)c1cc(O)c(O)c(O)c1
Storage condition	2-8°C

(-)-Epicatechin gallate MSDS(Chinese)

CHEMICAL IDENTIFICATION

RTECS NUMBER :: DH9030000

CHEMICAL NAME :: Benzoic acid, 3,4,5-trihydroxy-, 2-(3,4-dihydroxyphenyl)-3,4-dihydro-5,7-dihydroxy-2H- 1- benzopyran-3-yl ester, (2R-cis)-

CAS REGISTRY NUMBER :: 1257-08-5

LAST UPDATED :: 199309

DATA ITEMS CITED :: 1

MOLECULAR FORMULA :: C22-H18-O10

MOLECULAR WEIGHT :: 442.40

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Oral

SPECIES OBSERVED :: Rodent - mouse

DOSE/DURATION :: >1 gm/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

REFERENCE :: JKXXAF Japanese Kokai Tokyo Koho Patents. (U.S. Patent and Trademark Office, Foreign Patents, Washington, DC 20231) Volume(issue)/page/year: #93-944

Personal Protective Equipment	Eyeshields;Gloves;type N95 (US);type P1 (EN143) respirator filter
Hazard Codes	Xn
RIDADR	NONH for all modes of transport
WGK Germany	3
RTECS	DH9030000

Precursor 8
CAS#:63604-98-8 3,5-bis(benzylo... CAS#:1486-48-2 3,4,5-TRIBENZYL... CAS#:1486-47-1 3,4,5-tris(phen... CAS#:20728-73-8 (2R-trans)-2-[3...
CAS#:87292-49-7 tetrabeuzyl-(-)... CAS#:87292-54-4 (2R)-2-[3,4-bis... CAS#:732298-08-7 (E)-3-[2,4-bis(... CAS#:732298-11-2 (+)-(1S,2S)-3-[...
DownStream 10
CAS#:108907-44-4 (-)-ecg-4''-o-me CAS#:1707-75-1 1,1-DIPHENYL-2-... CAS#:621-54-5 3-(3-Hydroxyphe... CAS#:31129-95-0 Benzenepentanoi...
CAS#:31129-94-9 5-(3,4-dihydrox... CAS#:191666-22-5 2(3H)-Furanone,... CAS#:149-91-7 Gallic acid CAS#:490-46-0 Epicatechin
CAS#:28543-07-9 Theaflavin-3'-g... CAS#:6500-64-7 5-(3-Methoxyphe...

Influence of different withering conditions on phenolic composition of Avanà, Chatus and Nebbiolo grapes for the production of 'Reinforced' wines.

Food Chem. 194 , 247-56, (2015)

The impact of postharvest withering rates on the phenolic composition of 'reinforced' wines produced with partially dehydrated grapes was evaluated. The study was performed on winegrape varieties with...

Effects of UV exclusion on the physiology and phenolic composition of leaves and berries of Vitis vinifera cv. Graciano.

J. Sci. Food Agric. 95(2) , 409-16, (2014)

Ultraviolet (UV) radiation induces adaptive responses that can be used for plant production improvement. The aim of this study was to assess the effect of solar UV exclusion on the physiology and phen...

Identification of Vitis vinifera L. grape berry skin color mutants and polyphenolic profile.

Food Chem. 194 , 117-27, (2015)

A germplasm set of twenty-five grapevine accessions, forming eleven groups of possible berry skin color mutants, were genotyped with twelve microsatellite loci, being eleven of them identified as true...

Name: Antibacterial activity against Staphylococcus epidermidis ATCC 0155 after 24 hrs by N...
Source: ChEMBL
Target: Staphylococcus epidermidis
External Id: CHEMBL1115800

Name: Inhibition against HIV- reverse transcriptase in cell culture at 20 ug/mL
Source: ChEMBL
Target: Reverse transcriptase/RNaseH
External Id: CHEMBL689636

Name: Antibacterial activity against Micrococcus luteus ATCC 10240 after 24 hrs by NCCLS me...
Source: ChEMBL
Target: Micrococcus luteus
External Id: CHEMBL1115799

Name: Inhibition of FabZ
Source: ChEMBL
Target: 3-hydroxyacyl-[acyl-carrier-protein] dehydratase
External Id: CHEMBL859169

Name: Antibacterial activity against Staphylococcus aureus ATCC 25923 after 24 hrs by NCCLS...
Source: ChEMBL
Target: Staphylococcus aureus
External Id: CHEMBL1115798

Name: Inhibition of FabI
Source: ChEMBL
Target: Enoyl-acyl-carrier protein reductase
External Id: CHEMBL859170

Name: Antibacterial activity against Enterococcus faecalis ATCC 29212 after 24 hrs by NCCLS...
Source: ChEMBL
Target: Enterococcus faecalis
External Id: CHEMBL1115797

Name: Binding affinity to BCL2
Source: ChEMBL
Target: Apoptosis regulator Bcl-2
External Id: CHEMBL937576

Name: Antifungal activity against Candida albicans ATCC 10231 after 24 to 72 hrs by NCCLS m...
Source: ChEMBL
Target: Candida albicans
External Id: CHEMBL1115808

Name: Dual reporter qHTS for antagonist of Pregnane X Receptor (hPXR) against the NCATS DSH...
Source: NCGC
External Id: DSHEA-v1-PXR-antagonist-CTF

Total 227, Current Page 1 of 23

Benzoic acid, 3,4,5- trihydroxy-, 2-(3,4-dihydroxyphenyl)-3,4-dihydro-5,7-dihydroxy-2H-1-benzopyran-3-ylester, (2R-cis)-,

MFCD00075936

Epicatechol, 3-gallate, (-)- (8CI)

ECG

(-)-cis-3,3',4',5,7-Pentahydroxyflavane 3-gallate

Benzoic acid, 3,4,5-trihydroxy-, (2R,3R)-2-(3,4-dihydroxyphenyl)-3,4-dihydro-5,7-dihydroxy-2H-1-benzopyran-3-yl ester

(−)-Epicatechin gallate,from green tea

(2R,3R)-2-(3,4-Dihydroxyphenyl)-5,7-dihydroxy-3,4-dihydro-2H-chromen-3-yl 3,4,5-trihydroxybenzoate

Epicatechin gallate

(-)-epicatechin-3-gallate

(-)-Epicatechingallate

(-)-epicatechin gallate

(−)-Epicatechin gallate

(-)-cis-2-(3,4-Dihydroxyphenyl)-3,4-dihydro-1(2H)-benzopyran-3,5,7-triol 3-gallate

The content on this webpage is sourced from various professional data sources. If you have any questions or concerns regarding the content, please feel free to contact service1@chemsrc.com.

Shanghai Nianxing Industrial Co., Ltd
China
Product Name: (-)-Epicatechin gallate
Price: Check
Purity: 98.0%
Delivery: 10 Day
Contact: Yang
Email: sales@echemcloud.com

BioBioPha
China
Product Name: (-)-Epicatechin gallate
Price: ￥Inquiry/5mg
Purity: 98.0%
Delivery: 10 Day
Contact: Xueping-Zheng
Email: 1477035482@qq.com

Dayang Chem (Hangzhou) Co., Ltd.
China
Product Name: (-)-Epicatechin gallate
Price: $Inquiry/100g $Inquiry/1kg $Inquiry/100kg $Inquiry/1000kg
Purity: 98.0%
Delivery: Inquiry
Contact: Ms Wang
Email: enquiry@dycnchem.com

naturewill
China
Product Name: (-)-Epicatechin gallate
Price: ￥Inquiry/5mg ￥Inquiry/20mg ￥Inquiry/100mg ￥Inquiry/1g
Purity: 98.0%
Delivery: Inquiry
Contact: Bella
Email: 3157321941@qq.com

Shanghai Amole Biotechnology Co., Ltd.
China
Product Name: (-)-Epicatechin gallate
Price: ￥Inquiry/100mg ￥Inquiry/10mg ￥Inquiry/1g ￥Inquiry/1mg
Purity: 98.0%
Delivery: Inquiry
Contact: Xiyao Wang
Email: 3623107365@qq.com

Shanghai Jizhi Biochemical Technology Co., Ltd
China
Product Name: (-)-Epicatechin gallate
Price: ￥498.0/20mg
Purity: 98.0%
Delivery: Inquiry
Contact: Liu jia
Email: 2130147988@qq.com

Get all suppliers and price by the below link:

(-)-Epicatechin gallate suppliers

Price: ￥390/5mg

Reference only. check more (-)-Epicatechin gallate price

(-)-Epicatechin gallate

Use of (-)-Epicatechin gallate

Names