2'-deoxyuridine

Modify Date: 2026-06-30 21:39:52

2'-deoxyuridine Structure
2'-deoxyuridine structure
 Common Name 2'-deoxyuridine
CAS Number 951-78-0 Molecular Weight 228.202
Density 1.5±0.1 g/cm3 Boiling Point N/A
Molecular Formula C9H12N2O5 Melting Point 167-169 °C(lit.)
MSDS USA Flash Point N/A

 Use of 2'-deoxyuridine


2'-Deoxyuridine could increase chromosome breakage and results in a decreased thymidylate synthetase activity. A known use of 2'-Deoxyuridine is as a precursor in the synthesis of Edoxudine.

 Names

This table lists Chinese names, IUPAC names and various aliases of this chemical substance.

Name 2'-deoxyuridine
Synonym More Synonyms

 2'-deoxyuridine Biological Activity

This table contains bioactivity, target information and biological‑assay experimental data of this compound.

Description 2'-Deoxyuridine could increase chromosome breakage and results in a decreased thymidylate synthetase activity. A known use of 2'-Deoxyuridine is as a precursor in the synthesis of Edoxudine.
Related Catalog
Target

Human Endogenous Metabolite

References

[1]. Reidy JA, et al. Deoxyuridine increases folate-sensitive fragile site expression in human lymphocytes. Am J Med Genet. 1987 Jan;26(1):1-5.

 Chemical & Physical Properties

This table shows physicochemical parameters including melting point, boiling point, density, solubility and optical rotation. Missing data is marked as N/A.

Density 1.5±0.1 g/cm3
Melting Point 167-169 °C(lit.)
Molecular Formula C9H12N2O5
Molecular Weight 228.202
Exact Mass 228.074615
PSA 104.55000
LogP -1.70
Index of Refraction 1.603
InChIKey MXHRCPNRJAMMIM-UHFFFAOYSA-N
SMILES O=c1ccn(C2CC(O)C(CO)O2)c(=O)[nH]1
Storage condition 0-6°C
Water Solubility 300 g/L (20 ºC)

 MSDS

This table provides MSDS information including hazard classification, first‑aid, fire‑fighting, spill handling, operation and storage instructions.

 Toxicological Information

This table summarizes toxicological test data, acute & chronic toxicity and ecological hazard parameters for this chemical.

CHEMICAL IDENTIFICATION

RTECS NUMBER :
YU7490000
CHEMICAL NAME :
Uridine, 2'-deoxy-
CAS REGISTRY NUMBER :
951-78-0
BEILSTEIN REFERENCE NO. :
0024433
LAST UPDATED :
199701
DATA ITEMS CITED :
5
MOLECULAR FORMULA :
C9-H12-N2-O5
MOLECULAR WEIGHT :
228.23

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

MUTATION DATA

TYPE OF TEST :
Mutation in mammalian somatic cells
TEST SYSTEM :
Rodent - hamster Lung
DOSE/DURATION :
1 mmol/L
REFERENCE :
BICMBE Biochimie. (SPPIF, B.P.22, F-41353 Vineuil, France) V.53- 1971- Volume(issue)/page/year: 64,809,1982

 Safety Information

This table covers safety warnings, protective measures, incompatible substances and disposal guidelines for this compound.

Personal Protective Equipment Eyeshields;Gloves;type N95 (US);type P1 (EN143) respirator filter
Hazard Codes Xn
Risk Phrases R36/37/38
Safety Phrases S22-S24/25-S37/39
RIDADR NONH for all modes of transport
WGK Germany 3
RTECS YU7490000

 Synthetic Route

This table presents publicly reported synthetic routes, reaction conditions, reactants and product information of the compound.

 Articles46

More Articles

This table lists relevant public references with title, journal and publication metadata for this compound.

Simultaneous quantification of purine and pyrimidine bases, nucleosides and their degradation products in bovine blood plasma by high performance liquid chromatography tandem mass spectrometry.

J. Chromatogr. A. 1356 , 197-210, (2014)

Improved nitrogen utilization in cattle is important in order to secure a sustainable cattle production. As purines and pyrimidines (PP) constitute an appreciable part of rumen nitrogen, an improved u...

Phase I study of oral gemcitabine prodrug (LY2334737) in Japanese patients with advanced solid tumors.

Cancer Chemother. Pharmacol. 71(6) , 1645-55, (2013)

LY2334737 is an oral gemcitabine prodrug. This Phase I study assessed the safety and tolerability of LY2334737 in Japanese patients with solid tumors and evaluated pharmacokinetics (PK), pharmacodynam...

Quantitative structure-activity relationship and complex network approach to monoamine oxidase A and B inhibitors.

J. Med. Chem. 51 , 6740-51, (2008)

The work provides a new model for the prediction of the MAO-A and -B inhibitor activity by the use of combined complex networks and QSAR methodologies. On the basis of the obtained model, we prepared ...

 2'-deoxyuridineBioassay

View more

This table contains target information, in‑vitro & in‑vivo assay data for this compound.

Name: Primary cell-based high-throughput screening assay for identification of compounds th...
Source: Johns Hopkins Ion Channel Center
Target: regulator of G-protein signaling 4 isoform 2 [Homo sapiens]
External Id: JHICC_RGS_Act_HTS
Name: Luminescence-based cell-based primary high throughput screening assay to identify ago...
Source: The Scripps Research Institute Molecular Screening Center
Target: mu-type opioid receptor isoform MOR-1 [Homo sapiens]
External Id: OPRM1-OPRD1_AG_LUMI_1536_1X%ACT PRUN
Name: Inhibition constant was determined for the facilitated transport of [3N]-thymidine by...
Source: ChEMBL
Target: N/A
External Id: CHEMBL882650
Name: QFRET-based biochemical primary high throughput screening assay to identify exosite i...
Source: The Scripps Research Institute Molecular Screening Center
Target: disintegrin and metalloproteinase domain-containing protein 17 preproprotein [Homo sapiens]
External Id: ADAM17_INH_QFRET_1536_1X%INH PRUN
Name: Fluorescence-based cell-based primary high throughput screening assay to identify ago...
Source: The Scripps Research Institute Molecular Screening Center
Target: muscarinic acetylcholine receptor M1 [Homo sapiens]
External Id: CHRM1_AG_FLUO8_1536_1X%ACT PRUN
Name: Inhibitory activity against deoxycytidine kinase from L1210 cells
Source: ChEMBL
Target: Deoxycytidine kinase
External Id: CHEMBL663655
Name: uHTS identification of small molecule activators of the adaptive arm of the Unfolded ...
Source: Burnham Center for Chemical Genomics
Target: N/A
External Id: BCCG-A405-UPR-XBP1-PrimaryAgonist-Assay
Name: Fluorescence polarization to screen for inhibitor that competite the binding of FadD2...
Source: Broad Institute
Target: FATTY-ACID-CoA LIGASE FADD28 (FATTY-ACID-CoA SYNTHETASE)
External Id: 2147-01_Inhibitor_SinglePoint_HTS_Activity
Name: Bursicon-induced LGR2 mediated cAMP production in LGR-2/CRE6x-Luciferase co-transfect...
Source: Broad Institute
Target: N/A
External Id: Bursicon-induced LGR2 mediated cAMP production in LGR-2/CRE6x-Luciferase co-transfected HEK293 cells Inhibition - 7011-01_Antagonist_SinglePoint_HTS_Activity
Name: Dicer-mediated maturation of pre-microRNA
Source: Center for Chemical Genomics, University of Michigan
Target: N/A
External Id: TargetID_659_CEMA
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 Synonyms

This table collects all English aliases, systematic names and CAS‑related synonyms of the compound.

Uracildeoxyr
deoxyuridine
1-(2-Deoxy-β-D-erythro-pentofuranosyl)-4-hydroxy-2(1H)-pyrimidinone
T6NVMVJ A- ET5OTJ B1Q CQ &&Ribo-β-D Form
2'-deoxy-uridin
1-(2-Deoxy-b-D-erythro-pentofuranosyl)uracil
[131I]-Deoxyuridine
2'-Deoxyuridine
Desoxyuridine
MFCD00006527
2'-dU
EINECS 213-455-7
1-(2-Deoxy-D-erythro-pentofuranosyl)uracil
Deoxyribose uracil
1-(2-deoxy-β-D-ribofuranosyl)-2,4(1H,3H)-Pyrimidinedione
Deoxy-uridin
2′-Deoxyuridine
[3H]-Deoxyuridine
1-(2-deoxy-β-D-erythro-pentofuranosyl)uracil
1-(2-deoxy-β-δ-erythro-pentofuranosyl)-2,4(1H,3H)-Pyrimidinedione
1-((2R,4S,5R)-4-Hydroxy-5-(hydroxymethyl)tetrahydrofuran-2-yl)pyrimidine-2,4(1H,3H)-dione
durd
1-[(2R,4S,5R)-4-Hydroxy-5-(hydroxymethyl)tetrahydro-2-furanyl]-2,4(1H,3H)-pyrimidinedione
1-(2-deoxy-β-δ-ribofuranosyl)-2,4(1H,3H)-Pyrimidinedione
DEOXYURIDINE-2'
1-(2-deoxy-β-D-erythro-pentofuranosyl)-2,4(1H,3H)-Pyrimidinedione
1-(2-Deoxy-β-D-erythro-pentofuranosyl)pyrimidin-2,4(1H,3H)-dion
2'-DEOXYTHYMIDINE-5'-DIPHOSPHATE TRISODIUM SALT
1-(2-Deoxy-δ-erythro-pentofuranosyl)uracil

 2'-deoxyuridine | FAQ

This section contains frequently‑asked‑questions about this compound, including basic parameters, properties, storage conditions and corresponding answers.

Q: What is the SMILES notation of 2'-deoxyuridine?
A: SMILES notation of 2'-deoxyuridine is O=c1ccn(C2CC(O)C(CO)O2)c(=O)[nH]1.
Q: What is the safety information for 2'-deoxyuridine?
A: Safety information for 2'-deoxyuridine: S22-S24/25-S37/39.
Q: What is the English name of 2'-deoxyuridine?
A: The English name of 2'-deoxyuridine is 2'-deoxyuridine.
Q: What are the uses of 2'-deoxyuridine?
A: Main uses of 2'-deoxyuridine: 2'-Deoxyuridine could increase chromosome breakage and results in a decreased thymidylate synthetase activity. A known use of 2'-Deoxyuridine is as a precursor in the synthesis of Edoxudine.
Q: What is the CAS number of 2'-deoxyuridine?
A: CAS number of 2'-deoxyuridine is 951-78-0.
Q: What is the molecular weight of 2'-deoxyuridine?
A: Molecular weight of 2'-deoxyuridine is 228.202.
Q: What is the InChIKey of 2'-deoxyuridine?
A: InChIKey of 2'-deoxyuridine is MXHRCPNRJAMMIM-UHFFFAOYSA-N.
Q: What is the polar surface area (PSA) of 2'-deoxyuridine?
A: Polar surface area (PSA) of 2'-deoxyuridine is 104.55000.
Q: How is the water solubility of 2'-deoxyuridine?
A: Water solubility of 2'-deoxyuridine: 300 g/L (20 ºC).
Q: What is the molecular formula of 2'-deoxyuridine?
A: Molecular formula of 2'-deoxyuridine is C9H12N2O5.

 2'-deoxyuridinefactory

This table lists manufacturers and suppliers of this compound, including vendor names and product supply reference information.

Shanghai Nianxing Industrial Co., Ltd
BioBioPha
Dayang Chem (Hangzhou) Co., Ltd.
Henan Tianfu Chemical Co., Ltd.
Zhongshan Xingrui Chemical Co. , Ltd.
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Chemsrc provides 2'-deoxyuridine(CAS#:951-78-0) MSDS, density, melting point, boiling point, structure, formula, molecular weight etc. Articles of 2'-deoxyuridine are included as well.>> amp version: 2'-deoxyuridine

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