Bioorganic & Medicinal Chemistry Letters 2009-01-15

Antibacterial alkoxybenzamide inhibitors of the essential bacterial cell division protein FtsZ.

Lloyd G Czaplewski, Ian Collins, E Andrew Boyd, David Brown, Stephen P East, Mihaly Gardiner, Rowena Fletcher, David J Haydon, Vincent Henstock, Peter Ingram, Clare Jones, Caterina Noula, Leanne Kennison, Chris Rockley, Valerie Rose, Helena B Thomaides-Brears, Rebecca Ure, Mark Whittaker, Neil R Stokes

Index: Bioorg. Med. Chem. Lett. 19 , 524-7, (2009)

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Abstract

3-Methoxybenzamide is a weak inhibitor of the essential bacterial cell division protein FtsZ. Exploration of the structure-activity relationships of 3-methoxybenzamide analogues led to the identification of potent anti-staphylococcal compounds.