Synthesis

N-arylations of nitrogen-containing heterocycles with aryl and heteroaryl halides using a copper (I) oxide nanoparticle/1, 10-phenanthroline catalytic system

BX Tang, SM Guo, MB Zhang, JH Li

Index: Tang, Bo-Xiao; Guo, Sheng-Mei; Zhang, Man-Bo; Li, Jin-Heng Synthesis, 2008 , # 11 p. 1707 - 1716

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Citation Number: 26

Abstract

Abstract A general procedure for solvent-free N-arylations of nitrogen-containing heterocycles, ie imidazoles, triazoles, and indoles, with aryl and heteroaryl halides catalyzed by copper (I) oxide (Cu 2 O) nanoparticles is demonstrated. Four types of Cu 2 O were evaluated: the bulky compound and its cubic, octahedral, and spherical nanoparticulate forms. The results show that Cu 2 O nanoparticles, in particular the cubic form, are highly ...