Synlett

Copper-catalyzed N-Arylation of amides and azoles using phosphine-free hydrazone ligands

T Mino, Y Harada, H Shindo, M Sakamoto, T Fujita

Index: Mino, Takashi; Harada, Yoshikazu; Shindo, Hiroaki; Sakamoto, Masami; Fujita, Tsutomu Synlett, 2008 , # 4 p. 614 - 620

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Citation Number: 35

Abstract

Abstract Phosphine-free hydrazone such as 1c was found to be an efficient ligand for the copper-catalyzed Goldberg-type N-arylation of amides and Ullmann-type N-arylation of azoles with aryl halides under mild conditions. A variety of N-arylamides and N-arylazoles were synthesized in good to high yields.