Toxicology Letters 2013-11-25

Crotonaldehyde induces heat shock protein 72 expression that mediates anti-apoptotic effects in human endothelial cells

Dong Sun Ryu, Hana Yang, Seung Eun Lee, Cheung-Seog Park, Young-Ho Jin, Yong Seek Park

Index: Toxicol. Lett. 223(2) , 116-23, (2013)

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Abstract

• Crotonaldehyde induces HSP72 up-regulation in HUVECs. • HSP72 induction is mediated by JNK-HSF1 pathway. • HSP72 expression by crotonaldehyde requires calcium ions and ROS. • Up-regulation of HSP72 protects against crotonaldehyde-induced apoptosis in HUVECs.