BAPTA
BAPTA structure
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Common Name | BAPTA | ||
|---|---|---|---|---|
| CAS Number | 85233-19-8 | Molecular Weight | 476.433 | |
| Density | 1.5±0.1 g/cm3 | Boiling Point | 766.6±60.0 °C at 760 mmHg | |
| Molecular Formula | C22H24N2O10 | Melting Point | 177-179 °C | |
| MSDS | USA | Flash Point | 417.4±32.9 °C | |
| Symbol |
GHS07 |
Signal Word | Warning | |
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The Ca²⁺-calmodulin-Ca²⁺/calmodulin-dependent protein kinase II signaling pathway is involved in oxidative stress-induced mitochondrial permeability transition and apoptosis in isolated rat hepatocytes.
Arch. Toxicol. 88(9) , 1695-709, (2014) Oxidative stress (OS) is a common event in most hepatopathies, leading to mitochondrial permeability transition pore (MPTP) formation and further exacerbation of both OS from mitochondrial origin and cell death. Intracellular Ca²⁺ increase plays a permissive ... |
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Activation of epidermal growth factor receptor is required for Chlamydia trachomatis development.
BMC Microbiol. 14 , 277, (2015) Chlamydia trachomatis (C. trachomatis) is a clinically significant human pathogen and one of the leading causative agents of sexually transmitted diseases. As obligate intracellular bacteria, C. trachomatis has evolved strategies to redirect the host's signal... |
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HD iPSC-derived neural progenitors accumulate in culture and are susceptible to BDNF withdrawal due to glutamate toxicity.
Hum. Mol. Genet. 24 , 3257-71, (2015) Huntington's disease (HD) is a fatal neurodegenerative disease, caused by expansion of polyglutamine repeats in the Huntingtin gene, with longer expansions leading to earlier ages of onset. The HD iPSC Consortium has recently reported a new in vitro model of ... |
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The endogenous caspase-8 inhibitor c-FLIPL regulates ER morphology and crosstalk with mitochondria.
Cell Death Differ. 22 , 1131-43, (2015) Components of the death receptor-mediated pathways like caspase-8 have been identified in complexes at intracellular membranes to spatially restrict the processing of local targets. In this study, we report that the long isoform of the cellular FLICE-inhibito... |
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Cation binding site of cytochrome c oxidase: progress report.
Biochim. Biophys. Acta 1837(7) , 1188-95, (2014) Cytochrome c oxidase from bovine heart binds Ca(2+) reversibly at a specific Cation Binding Site located near the outer face of the mitochondrial membrane. Ca(2+) shifts the absorption spectrum of heme a, which allowed earlier the determination of the kinetic... |
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Activity-dependent upregulation of presynaptic kainate receptors at immature CA3-CA1 synapses.
J. Neurosci. 34(50) , 16902-16, (2014) Presynaptic kainate-type glutamate receptors (KARs) regulate glutamate release probability and short-term plasticity in various areas of the brain. Here we show that long-term depression (LTD) in the area CA1 of neonatal rodent hippocampus is associated with ... |
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Endothelin-1 protects human melanocytes from UV-induced DNA damage by activating JNK and p38 signalling pathways.
Exp. Dermatol. 24(4) , 269-74, (2015) Endothelin-1 is a paracrine factor with mitogenic, melanogenic and survival effects on cultured human melanocytes. We report that endothelin-1 signalling reduced the generation and enhanced the repair of ultraviolet radiation (UV)-induced DNA photoproducts, a... |
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Cell death caused by quinazolinone HMJ-38 challenge in oral carcinoma CAL 27 cells: dissections of endoplasmic reticulum stress, mitochondrial dysfunction and tumor xenografts.
Biochim. Biophys. Acta 1840(7) , 2310-20, (2014) This investigation clearly clarified the synthesized and antimitotic compound, 2-(3'-methoxyphenyl)-6-pyrrolidinyl-4-quinazolinone (HMJ-38), addressing its target and precise mechanism of action. We hypothesized that HMJ-38 might sensitize apoptotic death of ... |
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Thrombin-facilitated efflux of D-[3H]-aspartate from cultured astrocytes and neurons under hyponatremia and chemical ischemia.
Neurochem. Res. 39(7) , 1219-31, (2014) Thrombin effect increasing swelling-induced glutamate efflux was examined in cultured cortical astrocytes, cerebellar granule neurons (CGN), hippocampal and cortical neurons. Hypotonic glutamate efflux (monitored by D-[(3)H]aspartate) from cortical astrocytes... |
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Subthreshold IKK activation modulates the effector functions of primary mast cells and allows specific targeting of transformed mast cells.
Oncotarget 6(7) , 5354-68, (2015) Mast cell differentiation and proliferation depends on IL-3. IL-3 induces the activation of MAP-kinases and STATs and consequently induces proliferation and survival. Dysregulation of IL-3 signaling pathways also contribute to inflammation and tumorigenesis. ... |