Journal of Thoracic and Cardiovascular Surgery 2014-05-01

Effect of severe acidosis on vasoactive effects of epinephrine and norepinephrine in human distal mammary artery.

Charles Vidal, Stanislas Grassin-Delyle, Philippe Devillier, Emmanuel Naline, Emmanuel Lansac, Philippe M_nasch_, Christophe Faisy

Index: J. Thorac. Cardiovasc. Surg. 147(5) , 1698-705, (2014)

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Abstract

Acidosis is a very common pathologic process in perioperative management. However, how to correct severe acidosis to improve the efficacy of vasoconstrictors in hemodynamically unstable patients is still debated. The present study investigated whether severe extracellular acidosis influences the vasoactive properties of vasoconstrictors on human isolated arteries.