methoxamine hydrochloride

Modify Date: 2025-08-22 22:16:38

methoxamine hydrochloride structure	Common Name	methoxamine hydrochloride
	CAS Number	61-16-5	Molecular Weight	247.71900
	Density	N/A	Boiling Point	368.4ºC at 760 mmHg
	Molecular Formula	C₁₁H₁₈ClNO₃	Melting Point	212-216ºC
	MSDS	USA	Flash Point	176.6ºC

Use of methoxamine hydrochloride

Methoxamine hydrochloride is a noradrenergic α1 agonistsup>[1].

Name	2-amino-1-(2,5-dimethoxyphenyl)propan-1-ol,hydrochloride
Synonym	More Synonyms

Description	Methoxamine hydrochloride is a noradrenergic α1 agonistsup>[1].
Related Catalog	Signaling Pathways >> GPCR/G Protein >> Adrenergic Receptor Research Areas >> Neurological Disease
Target	Noradrenergic α1[1].
In Vitro	Methoxamine produces a dose-related increase in force development of the cat papillary muscle that was selectively blocked by alpha-adrenergic antagonists. This is suggestive evidence of the presence of alpha-adrenergic receptors in ventricular myocardium[1]. Methoxamine greatly enhances bistable behavior in the decerebrate. Methoxamine approximately doubles the amplitude of IPIC without changing its onset voltage, its offset voltage, or its persistence[2].
References	[1]. Rabinowitz B, et al. Positive inotropic effects of methoxamine: evidence for alpha-adrenergic receptors in ventricular myocardium. Am J Physiol. 1975 Sep;229(3):582-5. [2]. Lee RH, et al. Enhancement of bistability in spinal motoneurons in vivo by the noradrenergic alpha1 agonist methoxamine. J Neurophysiol. 1999 May;81(5):2164-74.

Boiling Point	368.4ºC at 760 mmHg
Melting Point	212-216ºC
Molecular Formula	C₁₁H₁₈ClNO₃
Molecular Weight	247.71900
Flash Point	176.6ºC
Exact Mass	247.09800
PSA	64.71000
LogP	2.58670
Index of Refraction	1.5204
Storage condition	2-8°C

methoxamine hydrochloride MSDS(Chinese)

CHEMICAL IDENTIFICATION

RTECS NUMBER :: DN4025000

CHEMICAL NAME :: Benzyl alcohol, alpha-(1-aminoethyl)-2,5-dimethoxy-, hydrochloride

CAS REGISTRY NUMBER :: 61-16-5

LAST UPDATED :: 199612

DATA ITEMS CITED :: 6

MOLECULAR FORMULA :: C11-H17-N-O3.Cl-H

MOLECULAR WEIGHT :: 247.75

WISWESSER LINE NOTATION :: ZY1&YQR BO1 EO1 &GH

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

TYPE OF TEST :: LDLo - Lowest published lethal dose

ROUTE OF EXPOSURE :: Oral

SPECIES OBSERVED :: Rodent - mouse

DOSE/DURATION :: 135 mg/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

REFERENCE :: 27ZIAQ "Drug Dosages in Laboratory Animals - A Handbook," Rev. ed., Barnes, C.D., and L.G. Eltherington, Berkeley, Univ. of California Press, 1973 Volume(issue)/page/year: -,160,1973

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Intraperitoneal

SPECIES OBSERVED :: Rodent - mouse

DOSE/DURATION :: 92 mg/kg

TOXIC EFFECTS :: Sense Organs and Special Senses (Eye) - effect, not otherwise specified Behavioral - somnolence (general depressed activity) Gastrointestinal - changes in structure or function of salivary glands

REFERENCE :: JPETAB Journal of Pharmacology and Experimental Therapeutics. (Williams & Wilkins Co., 428 E. Preston St., Baltimore, MD 21202) V.1- 1909/10- Volume(issue)/page/year: 92,283,1948

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Intravenous

SPECIES OBSERVED :: Rodent - mouse

DOSE/DURATION :: 5030 ug/kg

TOXIC EFFECTS :: Behavioral - convulsions or effect on seizure threshold Lungs, Thorax, or Respiration - dyspnea Lungs, Thorax, or Respiration - other changes

REFERENCE :: EJPHAZ European Journal of Pharmacology. (Elsevier Science Pub. B.V., POB 211, 1000 AE Amsterdam, Netherlands) V.1- 1967- Volume(issue)/page/year: 9,289,1970 ** REPRODUCTIVE DATA **

TYPE OF TEST :: TDLo - Lowest published toxic dose

ROUTE OF EXPOSURE :: Implant

DOSE :: 400 mg/kg

SEX/DURATION :: male 1 day(s) pre-mating

TOXIC EFFECTS :: Reproductive - Paternal Effects - spermatogenesis (incl. genetic material, sperm morphology, motility, and count) Reproductive - Fertility - male fertility index (e.g. # males impregnating females per # males exposed to fertile nonpregnant females) Reproductive - Fertility - litter size (e.g. # fetuses per litter; measured before birth)

REFERENCE :: JRPFA4 Journal of Reproduction and Fertility. (Biochemical Soc. Book Depot, POB 32, Commerce Way, Colchester, Essex CO2 8HP, UK) V.1- 1960- Volume(issue)/page/year: 58,19,1980

TYPE OF TEST :: TDLo - Lowest published toxic dose

ROUTE OF EXPOSURE :: Intratesticular

DOSE :: 400 mg/kg

SEX/DURATION :: male 21 day(s) pre-mating

TOXIC EFFECTS :: Reproductive - Paternal Effects - spermatogenesis (incl. genetic material, sperm morphology, motility, and count) Reproductive - Fertility - male fertility index (e.g. # males impregnating females per # males exposed to fertile nonpregnant females) Reproductive - Fertility - litter size (e.g. # fetuses per litter; measured before birth)

REFERENCE :: JRPFA4 Journal of Reproduction and Fertility. (Biochemical Soc. Book Depot, POB 32, Commerce Way, Colchester, Essex CO2 8HP, UK) V.1- 1960- Volume(issue)/page/year: 58,19,1980 *** NIOSH STANDARDS DEVELOPMENT AND SURVEILLANCE DATA *** NIOSH OCCUPATIONAL EXPOSURE SURVEY DATA : NOES - National Occupational Exposure Survey (1983) NOES Hazard Code - X5310 No. of Facilities: 23 (estimated) No. of Industries: 1 No. of Occupations: 3 No. of Employees: 988 (estimated) No. of Female Employees: 625 (estimated)

Personal Protective Equipment	Eyeshields;Gloves;type N95 (US);type P1 (EN143) respirator filter
RIDADR	NONH for all modes of transport
WGK Germany	3
RTECS	DN4025000

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Methoxamine HCl

(1RS,2SR)-2-amino-1-(2,5-dimethoxy-phenyl)-propan-1-ol,hydrochloride

Methoxamini hydrochloridum

METHOXAMINE HYDROCHLORIDE

EINECS 200-499-7

Pressomin hydrochloride

Idasal

Vasoxyl hydrochloride

(1RS,2SR)-2-Amino-1-(2,5-dimethoxy-phenyl)-propan-1-ol,Hydrochlorid

MFCD00058607

Vasylox hydrochloride

2-amino-1-(2,5-dimethoxyphenyl)-1-propanol monohydrochloride

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