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61-16-5

61-16-5 structure
61-16-5 structure
Name 2-amino-1-(2,5-dimethoxyphenyl)propan-1-ol,hydrochloride
Synonyms Methoxamine HCl
(1RS,2SR)-2-amino-1-(2,5-dimethoxy-phenyl)-propan-1-ol,hydrochloride
Methoxamini hydrochloridum
METHOXAMINE HYDROCHLORIDE
EINECS 200-499-7
Pressomin hydrochloride
Idasal
Vasoxyl hydrochloride
(1RS,2SR)-2-Amino-1-(2,5-dimethoxy-phenyl)-propan-1-ol,Hydrochlorid
MFCD00058607
Vasylox hydrochloride
2-amino-1-(2,5-dimethoxyphenyl)-1-propanol monohydrochloride
Description Methoxamine hydrochloride is a noradrenergic α1 agonistsup>[1].
Related Catalog
Target

Noradrenergic α1[1].
In Vitro Methoxamine produces a dose-related increase in force development of the cat papillary muscle that was selectively blocked by alpha-adrenergic antagonists. This is suggestive evidence of the presence of alpha-adrenergic receptors in ventricular myocardium[1]. Methoxamine greatly enhances bistable behavior in the decerebrate. Methoxamine approximately doubles the amplitude of IPIC without changing its onset voltage, its offset voltage, or its persistence[2].
References

[1]. Rabinowitz B, et al. Positive inotropic effects of methoxamine: evidence for alpha-adrenergic receptors in ventricular myocardium. Am J Physiol. 1975 Sep;229(3):582-5.

[2]. Lee RH, et al. Enhancement of bistability in spinal motoneurons in vivo by the noradrenergic alpha1 agonist methoxamine. J Neurophysiol. 1999 May;81(5):2164-74.
Boiling Point 368.4ºC at 760 mmHg
Melting Point 212-216ºC
Molecular Formula C11H18ClNO3
Molecular Weight 247.71900
Flash Point 176.6ºC
Exact Mass 247.09800
PSA 64.71000
LogP 2.58670
Index of Refraction 1.5204
Storage condition 2-8°C

CHEMICAL IDENTIFICATION

RTECS NUMBER :
DN4025000
CHEMICAL NAME :
Benzyl alcohol, alpha-(1-aminoethyl)-2,5-dimethoxy-, hydrochloride
CAS REGISTRY NUMBER :
61-16-5
LAST UPDATED :
199612
DATA ITEMS CITED :
6
MOLECULAR FORMULA :
C11-H17-N-O3.Cl-H
MOLECULAR WEIGHT :
247.75
WISWESSER LINE NOTATION :
ZY1&YQR BO1 EO1 &GH

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

TYPE OF TEST :
LDLo - Lowest published lethal dose
ROUTE OF EXPOSURE :
Oral
SPECIES OBSERVED :
Rodent - mouse
DOSE/DURATION :
135 mg/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
REFERENCE :
27ZIAQ "Drug Dosages in Laboratory Animals - A Handbook," Rev. ed., Barnes, C.D., and L.G. Eltherington, Berkeley, Univ. of California Press, 1973 Volume(issue)/page/year: -,160,1973
TYPE OF TEST :
LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE :
Intraperitoneal
SPECIES OBSERVED :
Rodent - mouse
DOSE/DURATION :
92 mg/kg
TOXIC EFFECTS :
Sense Organs and Special Senses (Eye) - effect, not otherwise specified Behavioral - somnolence (general depressed activity) Gastrointestinal - changes in structure or function of salivary glands
REFERENCE :
JPETAB Journal of Pharmacology and Experimental Therapeutics. (Williams & Wilkins Co., 428 E. Preston St., Baltimore, MD 21202) V.1- 1909/10- Volume(issue)/page/year: 92,283,1948
TYPE OF TEST :
LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE :
Intravenous
SPECIES OBSERVED :
Rodent - mouse
DOSE/DURATION :
5030 ug/kg
TOXIC EFFECTS :
Behavioral - convulsions or effect on seizure threshold Lungs, Thorax, or Respiration - dyspnea Lungs, Thorax, or Respiration - other changes
REFERENCE :
EJPHAZ European Journal of Pharmacology. (Elsevier Science Pub. B.V., POB 211, 1000 AE Amsterdam, Netherlands) V.1- 1967- Volume(issue)/page/year: 9,289,1970 ** REPRODUCTIVE DATA **
TYPE OF TEST :
TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE :
Implant
DOSE :
400 mg/kg
SEX/DURATION :
male 1 day(s) pre-mating
TOXIC EFFECTS :
Reproductive - Paternal Effects - spermatogenesis (incl. genetic material, sperm morphology, motility, and count) Reproductive - Fertility - male fertility index (e.g. # males impregnating females per # males exposed to fertile nonpregnant females) Reproductive - Fertility - litter size (e.g. # fetuses per litter; measured before birth)
REFERENCE :
JRPFA4 Journal of Reproduction and Fertility. (Biochemical Soc. Book Depot, POB 32, Commerce Way, Colchester, Essex CO2 8HP, UK) V.1- 1960- Volume(issue)/page/year: 58,19,1980
TYPE OF TEST :
TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE :
Intratesticular
DOSE :
400 mg/kg
SEX/DURATION :
male 21 day(s) pre-mating
TOXIC EFFECTS :
Reproductive - Paternal Effects - spermatogenesis (incl. genetic material, sperm morphology, motility, and count) Reproductive - Fertility - male fertility index (e.g. # males impregnating females per # males exposed to fertile nonpregnant females) Reproductive - Fertility - litter size (e.g. # fetuses per litter; measured before birth)
REFERENCE :
JRPFA4 Journal of Reproduction and Fertility. (Biochemical Soc. Book Depot, POB 32, Commerce Way, Colchester, Essex CO2 8HP, UK) V.1- 1960- Volume(issue)/page/year: 58,19,1980 *** NIOSH STANDARDS DEVELOPMENT AND SURVEILLANCE DATA *** NIOSH OCCUPATIONAL EXPOSURE SURVEY DATA : NOES - National Occupational Exposure Survey (1983) NOES Hazard Code - X5310 No. of Facilities: 23 (estimated) No. of Industries: 1 No. of Occupations: 3 No. of Employees: 988 (estimated) No. of Female Employees: 625 (estimated)
Personal Protective Equipment Eyeshields;Gloves;type N95 (US);type P1 (EN143) respirator filter
RIDADR NONH for all modes of transport
WGK Germany 3
RTECS DN4025000

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