Adrenaline
Adrenaline structure
|
Common Name | Adrenaline | ||
|---|---|---|---|---|
| CAS Number | 51-43-4 | Molecular Weight | 183.204 | |
| Density | 1.3±0.1 g/cm3 | Boiling Point | 413.1±40.0 °C at 760 mmHg | |
| Molecular Formula | C9H13NO3 | Melting Point | 208-211ºC | |
| MSDS | Chinese USA | Flash Point | 207.9±17.9 °C | |
| Symbol |
GHS06 |
Signal Word | Danger | |
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Over-expression of Follistatin-like 3 attenuates fat accumulation and improves insulin sensitivity in mice.
Metab. Clin. Exp. 64(2) , 283-95, (2015) Follistatin-like 3 (fstl3), a natural inhibitor of members of the TGF-β family, increases during resistance training in human plasma. Fstl3 primarily binds myostatin and activin A, and thereby inhibits their functions. We hypothesize that blocking myostatin a... |
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Phospholipase C-related catalytically inactive protein (PRIP) regulates lipolysis in adipose tissue by modulating the phosphorylation of hormone-sensitive lipase.
PLoS ONE 9(6) , e100559, (2014) Phosphorylation of hormone-sensitive lipase (HSL) and perilipin by protein kinase A (PKA) promotes the hydrolysis of lipids in adipocytes. Although activation of lipolysis by PKA has been well studied, inactivation via protein phosphatases is poorly understoo... |
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Endogenous brain pericytes are widely activated and contribute to mouse glioma microvasculature.
PLoS ONE 10(4) , e0123553, (2015) Glioblastoma multiforme (GBM) is the most common brain tumor in adults. It presents an extremely challenging clinical problem, and treatment very frequently fails due to the infiltrative growth, facilitated by extensive angiogenesis and neovascularization. Pe... |
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Cheminformatics analysis of assertions mined from literature that describe drug-induced liver injury in different species.
Chem. Res. Toxicol. 23 , 171-83, (2010) Drug-induced liver injury is one of the main causes of drug attrition. The ability to predict the liver effects of drug candidates from their chemical structures is critical to help guide experimental drug discovery projects toward safer medicines. In this st... |
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Translating clinical findings into knowledge in drug safety evaluation--drug induced liver injury prediction system (DILIps).
J. Sci. Ind. Res. 65(10) , 808, (2006) Drug-induced liver injury (DILI) is a significant concern in drug development due to the poor concordance between preclinical and clinical findings of liver toxicity. We hypothesized that the DILI types (hepatotoxic side effects) seen in the clinic can be tra... |
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Alpha-lipoic acid affects the oxidative stress in various brain structures in mice with methionine and choline deficiency.
Exp. Biol. Med. (Maywood.) 240(4) , 418-25, (2015) Deficiency in methionine or choline can induce oxidative stress in various organs such as liver, kidney, heart, and brain. This study was to examine the effects of alpha-lipoic acid (LA) on oxidative stress induced by methionine and choline deficiency (MCD) i... |
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Evaluation of cytogenetic and DNA damage in human lymphocytes treated with adrenaline in vitro.
Toxicol. In Vitro 29(1) , 27-33, (2014) Catechol groups can be involved in redox cycling accompanied by generation of reactive oxygen species (ROS) which may lead to oxidative damage of cellular macromolecules including DNA. The objective of this investigation was to evaluate possible genotoxic eff... |
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Structural requirements for drug inhibition of the liver specific human organic cation transport protein 1.
J. Med. Chem. 51 , 5932-42, (2008) The liver-specific organic cation transport protein (OCT1; SLC22A1) transports several cationic drugs including the antidiabetic drug metformin and the anticancer agents oxaliplatin and imatinib. In this study, we explored the chemical space of registered ora... |
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Computational modeling of novel inhibitors targeting the Akt pleckstrin homology domain.
Bioorg. Med. Chem. 17 , 6983-92, (2009) Computational modeling continues to play an important role in novel therapeutics discovery and development. In this study, we have investigated the use of in silico approaches to develop inhibitors of the pleckstrin homology (PH) domain of AKT (protein kinase... |
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QSAR-based permeability model for drug-like compounds.
Bioorg. Med. Chem. 19 , 2615-24, (2011) A QSAR model was developed for predicting intestinal drug permeability, one of the most important parameters when evaluating compounds in drug discovery projects. First, a set of relevant properties for establishing a drug-like chemical space was applied to a... |