(R)-(-)-Phenylephrine
(R)-(-)-Phenylephrine structure
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Common Name | (R)-(-)-Phenylephrine | ||
|---|---|---|---|---|
| CAS Number | 59-42-7 | Molecular Weight | 167.20500 | |
| Density | 1.159 g/cm3 | Boiling Point | 341.1ºC at 760 mmHg | |
| Molecular Formula | C9H13NO2 | Melting Point | 171°C | |
| MSDS | N/A | Flash Point | 163.4ºC | |
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Histamine H4 receptor as a new therapeutic target for choroidal neovascularization in age-related macular degeneration.
Br. J. Pharmacol. 171(15) , 3754-63, (2014) The present treatment for choroidal neovascularization (CNV) associated with age-related macular degeneration (AMD) is not sufficient. Hence, we examined the therapeutic efficacy of reducing histamine H4 receptor expression on CNV in mice.H4 receptor expressi... |
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Transscleral delivery of Nd: YLF laser at 1,047 nm causes vascular occlusion in experimental pigmented choroidal melanoma.
Retina (Philadelphia, Pa.) 34(4) , 792-800, (2014) The aims of this study were to determine the scleral attenuation of focused neodymium: yttrium-lanthanum-fluoride laser at 1,047 nm applied transsclerally and whether transscleral delivery can close the vascular supply at the base of experimental choroidal me... |
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Protective Effects of Human iPS-Derived Retinal Pigmented Epithelial Cells in Comparison with Human Mesenchymal Stromal Cells and Human Neural Stem Cells on the Degenerating Retina in rd1 mice.
Stem Cells 33(5) , 1543-53, (2015) Retinitis pigmentosa (RP) is a group of visual impairments characterized by progressive rod photoreceptor cell loss due to a genetic background. Pigment epithelium-derived factor (PEDF) predominantly secreted by the retinal pigmented epithelium (RPE) has been... |
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Effect of a sigma-1 receptor agonist, cutamesine dihydrochloride (SA4503), on photoreceptor cell death against light-induced damage.
Exp. Eye Res. 132 , 64-72, (2015) Cutamesine dihydrochloride is an agonist of sigma-1 receptor, which is a ligand-operated receptor chaperone at the mitochondrion-associated endoplasmic reticulum (ER) membrane. ER stress plays a pivotal role in light irradiation-induced retinal damage. In the... |
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Comparison of retinal nerve fiber layer thickness in vivo and axonal transport after chronic intraocular pressure elevation in young versus older rats.
PLoS ONE 9(12) , e114546, (2014) To compare in young and old rats longitudinal measurements of retinal nerve fiber layer thickness (RNFLT) and axonal transport 3-weeks after chronic IOP elevation.IOP was elevated unilaterally in 2- and 9.5-month-old Brown-Norway rats by intracameral injectio... |
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Simultaneous analysis of amphetamine-type stimulants in plasma by solid-phase microextraction and gas chromatography-mass spectrometry.
J. Anal. Toxicol. 38(7) , 432-7, (2014) Brazil is considered one of the countries with the highest number of amphetamine-type stimulant (ATS) users worldwide, mainly diethylpropion (DIE) and fenproporex (FEN). The use of ATS is mostly linked to diverted prescription stimulants and this misuse is wi... |
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Bisphenol A alters autonomic tone and extracellular matrix structure and induces sex-specific effects on cardiovascular function in male and female CD-1 mice.
Endocrinology 156(3) , 882-95, (2015) The aim of this study was to determine whether bisphenol A (BPA) has adverse effects on cardiovascular functions in CD-1 mice and define sex-specific modes of BPA action in the heart. Dams and analyzed progeny were maintained on a defined diet containing BPA ... |
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Role of C/EBP homologous protein in retinal ganglion cell death after ischemia/reperfusion injury.
Invest. Ophthalmol. Vis. Sci. 56(1) , 221-31, (2015) To investigate the role of C/EBP homologous protein (CHOP), a proapoptotic protein, and the unfolded protein response (UPR) marker that is involved in endoplasmic reticulum (ER) stress-mediated apoptosis in mouse retinal ganglion cell (RGC) death following is... |
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Tissue specific up regulation of ACE2 in rabbit model of atherosclerosis by atorvastatin: role of epigenetic histone modifications.
Biochem. Pharmacol. 93(3) , 343-51, (2015) Growing body of evidence points out the crucial role of ACE2 in preventing atherosclerosis. However, data on how atherosclerosis affects ACE2 expression in heart and kidney remains unknown. Atherosclerosis was induced by feeding New Zealand White rabbits with... |
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Curcumin analogues inhibit phosphodiesterase-5 and dilate rat pulmonary arteries.
J. Pharm. Pharmacol. 67(1) , 87-95, (2014) Phosphodiesterase (PDE)-5 inhibitors are useful as vasodilators for the treatment of pulmonary arterial hypertension. We aimed to study curcumin analogues for PDE5 inhibitory activity and vasorelaxation of rat pulmonary arteries.Three natural curcuminoids (1-... |