Norepinephrine
Norepinephrine structure
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Common Name | Norepinephrine | ||
|---|---|---|---|---|
| CAS Number | 51-41-2 | Molecular Weight | 169.178 | |
| Density | 1.4±0.1 g/cm3 | Boiling Point | 442.6±40.0 °C at 760 mmHg | |
| Molecular Formula | C8H11NO3 | Melting Point | 220-230°C | |
| MSDS | Chinese USA | Flash Point | 221.5±27.3 °C | |
| Symbol |
GHS06 |
Signal Word | Danger | |
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Cheminformatics analysis of assertions mined from literature that describe drug-induced liver injury in different species.
Chem. Res. Toxicol. 23 , 171-83, (2010) Drug-induced liver injury is one of the main causes of drug attrition. The ability to predict the liver effects of drug candidates from their chemical structures is critical to help guide experimental drug discovery projects toward safer medicines. In this st... |
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Translating clinical findings into knowledge in drug safety evaluation--drug induced liver injury prediction system (DILIps).
J. Sci. Ind. Res. 65(10) , 808, (2006) Drug-induced liver injury (DILI) is a significant concern in drug development due to the poor concordance between preclinical and clinical findings of liver toxicity. We hypothesized that the DILI types (hepatotoxic side effects) seen in the clinic can be tra... |
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Sympathetic activity induced by naloxone-precipitated morphine withdrawal is blocked in genetically engineered mice lacking functional CRF1 receptor.
Toxicol. Appl. Pharmacol. 283(1) , 42-9, (2015) There is large body evidence indicating that stress can lead to cardiovascular disease. However, the exact brain areas and the mechanisms involved remain to be revealed. Here, we performed a series of experiments to characterize the role of CRF1 receptor (CRF... |
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An assessment of norepinephrine mediated hypertrophy to apoptosis transition in cardiac cells: a signal for cell death.
Chem. Biol. Interact. 225 , 54-62, (2015) Heart is an organ which is under a constant work load that generates numerous stress responses. Heart failure is associated with increased plasma norepinephrine (NE) and hypertrophic cell death. Within the current study we try to understand the concentration ... |
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Relationship between noradrenaline release in the locus coeruleus and antiallodynic efficacy of analgesics in rats with painful diabetic neuropathy.
Life Sci. 92(23) , 1138-44, (2013) In animal models of neuropathic pain, the noradrenergic descending pain inhibitory pathways from the locus coeruleus (LC) may be suppressed. However, no study has investigated the correlation between noradrenaline (NA) release in the LC and efficacy of analge... |
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Prenatal exposure to permethrin influences vascular development of fetal brain and adult behavior in mice offspring.
Environ. Toxicol. 28(11) , 617-29, (2013) Pyrethroids are one of the most widely used classes of insecticides and show neurotoxic effects that induce oxidative stress in the neonatal rat brain. However, little is still known about effects of prenatal exposure to permethrin on vascular development in ... |
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Dopamine receptor antagonists as new mode-of-action insecticide leads for control of Aedes and Culex mosquito vectors.
PLoS Negl. Trop. Dis. 9(3) , e0003515, (2015) New mode-of-action insecticides are sought to provide continued control of pesticide resistant arthropod vectors of neglected tropical diseases (NTDs). We previously identified antagonists of the AaDOP2 D1-like dopamine receptor (DAR) from the yellow fever mo... |
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The water channel aquaporin-1 contributes to renin cell recruitment during chronic stimulation of renin production.
Am. J. Physiol. Renal Physiol. 307(11) , F1215-26, (2014) Both the processing and release of secretory granules involve water movement across granule membranes. It was hypothesized that the water channel aquaporin (AQP)1 directly contributes to the recruitment of renin-positive cells in the afferent arteriole. AQP1(... |
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Postoperative polymyxin B hemoperfusion and mortality in patients with abdominal septic shock: a propensity-matched analysis.
Crit. Care Med. 42(5) , 1187-93, (2014) To examine the effect of postoperative polymyxin B hemoperfusion on mortality in patients with abdominal septic shock triggered by lower gastrointestinal tract perforation, identifying subpopulations of patients who may benefit from this treatment.Propensity-... |
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Correlation of 3-mercaptopropionic acid induced seizures and changes in striatal neurotransmitters monitored by microdialysis.
Eur. J. Pharm. Sci. 57 , 25-33, (2014) The goal of this study was to use a status epilepticus steady-state chemical model in rats using the convulsant, 3-mercaptopropionic acid (3-MPA), and to compare the changes in striatal neurotransmission on a slow (5min) and fast (60s) timescale. In vivo micr... |